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pH Induced Conformational Transitions in the Transforming Growth Factor β-Induced Protein (TGFβIp) Associated Corneal Dystrophy Mutants

Murugan, Elavazhagan; Venkatraman, Anandalakshmi; Lei, Zhou; Mouvet, Victoria; Rui, Yi Lim Rayne; Muruganantham, Nandhakumar; Goh, Eunice; Swee, Lim Peh Gary; Beuerman, Roger W; Chaurasia, Shyam S; Rajamani, Lakshminarayanan; Mehta, Johnbir S (2016)
article

Most stromal corneal dystrophies are associated with aggregation and deposition of the mutated transforming growth factor-β induced protein (TGFβIp). The 4th_FAS1 domain of TGFβIp harbors ~80% of the mutations that forms ...