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Psychiatric medications and the risk of autoimmune and immune-mediated inflammatory diseases : A systematic review and meta-analysis of observational studies
(2023-02)
- article
Background Pharmacovigilance reports have suggested that certain commonly used medications may trigger autoimmune diseases (ADs) and immune-mediated inflammatory diseases (IMIDs). We systematically reviewed the literature ...
The interactomics of academia
(2023-01-26)
- article
Diminishing benefits of urban living for children and adolescents’ growth and development
(2023-03-30)
- article
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million ...
High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production
(2023-04-13)
- article
Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic megakaryocytes (LCM) are critical negative regulators ...
The Impact of Antenatal Azithromycin and Monthly Sulfadoxine-Pyrimethamine on Maternal Malaria during Pregnancy and Fetal Growth : A Randomized Controlled Trial
(2023-04-05)
- article
Maternal malaria and infections during pregnancy are risk factors for fetal growth restriction. We assessed the impact of preventive treatment in pregnancy on maternal malaria and fetal growth. Between 2003 and 2006, we ...
Geenit ja proteiinit kertovat lasten leukemian ennusteesta
(2022)
- article
Cell adhesion and culture medium dependent changes in the high frequency mechanical vibration induced proliferation, osteogenesis, and intracellular organization of human adipose stem cells
(2020)
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High frequency (HF) mechanical vibration appears beneficial for in vitro osteogenesis of mesenchymal stem cells (MSCs). However, the current mechanobiological understanding of the method remains insufficient. We designed ...
hiPSC-Derived Cardiomyocyte Model of LQT2 Syndrome Derived from Asymptomatic and Symptomatic Mutation Carriers Reproduces Clinical Differences in Aggregates but Not in Single Cells
(2020)
- article
Mutations in the HERG gene encoding the potassium ion channel HERG, represent one of the most frequent causes of long QT syndrome type-2 (LQT2). The same genetic mutation frequently presents different clinical phenotypes ...
A compartmentalized neuron-oligodendrocyte co-culture device for myelin research: design, fabrication and functionality testing
(2019)
- article
Microfluidics devices for co-culturing neurons and oligodendrocytes represent an important in vitro research tool to decipher myelination mechanisms in health and disease and in the identification of novel treatments for ...