Haku
Viitteet 91-100 / 120
Transcriptional Differences between Diapausing and Non-Diapausing D. montana Females Reared under the Same Photoperiod and Temperature
(2016)
- article
Background
A wide range of insects living at higher latitudes enter diapause at the end of the warm season, which increases their chances of survival through harsh winter conditions. In this study we used RNA sequencing ...
Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase
(2014)
- article
The machinery of mitochondrial DNA (mtDNA) maintenance is only partially characterized and is of wide interest due to its involvement in disease. To identify novel components of this machinery, plus other cellular pathways ...
New ways to make a blood cell
(2015)
- article
In a niche under the skin in Drosophila larvae, blood cells called plasmatocytes can transform into other classes of blood cell.
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
(2014)
- article
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated ...
Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots
(2016)
- article
Progression of malignancy to overt disease requires multiple genetic hits. Activation-induced deaminase (AID) can drive lymphomagenesis by generating off-target DNA breaks at loci that harbor highly active enhancers and ...
Immuno-onkologia - hopealuoteja vai joukkotuhoaseita
(2016)
- article
Luontaiset lymfosyytit - uusi immuunisoluryhmä
(2016)
- article
Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility
(2016)
- article
To understand how Toll signaling controls the activation of a cellular immune response in Drosophila blood cells (hemocytes), we carried out a genetic modifier screen, looking for deletions that suppress or enhance the ...
Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection
(2016)
- article
Cellular immune responses require the generation and recruitment of diverse blood cell types that recognize and kill pathogens. In Drosophila melanogaster larvae, immune-inducible lamellocytes participate in recognizing ...
Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer
(2016)
- article
The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved ...