Pulse Wave Analysis for Predicting Risk of a Cardiovascular Event
Kinnunen, Kalle (2019)
2019
Sähkötekniikka
Informaatioteknologian ja viestinnän tiedekunta - Faculty of Information Technology and Communication Sciences
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Hyväksymispäivämäärä
2019-05-23
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tty-201905311798
https://urn.fi/URN:NBN:fi:tty-201905311798
Tiivistelmä
As cardiovascular diseases are the leading cause of death in the world with approximately 17.9 million related deaths in 2016 alone, there is a great need to improve the diagnosis of these diseases and to prevent the following events. This problem is particularly important as 85% of these cases could be preventable.
Pulse wave analysis has been studied for finding markers or risk of various abnormalities including overall cardiovascular risk and peripheral artery disease. Arterial pulse wave analysis is based on measuring and evaluating arterial pulse waves that are pulsatile changes of the blood pressure caused by pumping of the heart. These methods could be utilized to improve the diagnosis of cardiovascular diseases and thus result in lowered number of events. This is based on the fact that these methods are non-invasive and have the potential to be widespread.
In this thesis, arterial pulse wave analysis methods were evaluated for their impact on relieving this issue by evaluating the different variables and methods in question and their actual clinical relevance. Also, a brief overall look to commercial measurement devices was implemented. The study was performed by carrying out a thorough literature survey from the related study fields.
Based on the literature, carotid-femoral Pulse Wave Velocity (cfPWV) was found to be the most prominent variable for predicting overall cardiovascular risk. Cardiovascular risk is the overall risk to have any cardiovascular disease and it also pertains to the risk of cardiovascular mortality.
cfPWV has essential reliability and reproducibility with competent guidelines, devices and standardization process in place. However, the standardization still needs further efforts for effective and comparable widespread clinical use. The need for standardization is mainly caused by the fact that the methods and devices are still not uniformly used.
Utilization of pulse wave analysis variables for improving the diagnosis of peripheral artery disease specifically was found to be worthwhile but further studies are still needed. One important aspect related to this is that until these methods are included into peripheral artery disease guidelines, there is no relevant clinical benefit available from them.
As a whole, pulse wave analysis methods are intensively studied as a tool for diagnosis, but the varieties in measurement and on analysis methods at clinical circumstances as well as lack of validation continue to be major obstacles that prevent these methods from breaking through.
Pulse wave analysis has been studied for finding markers or risk of various abnormalities including overall cardiovascular risk and peripheral artery disease. Arterial pulse wave analysis is based on measuring and evaluating arterial pulse waves that are pulsatile changes of the blood pressure caused by pumping of the heart. These methods could be utilized to improve the diagnosis of cardiovascular diseases and thus result in lowered number of events. This is based on the fact that these methods are non-invasive and have the potential to be widespread.
In this thesis, arterial pulse wave analysis methods were evaluated for their impact on relieving this issue by evaluating the different variables and methods in question and their actual clinical relevance. Also, a brief overall look to commercial measurement devices was implemented. The study was performed by carrying out a thorough literature survey from the related study fields.
Based on the literature, carotid-femoral Pulse Wave Velocity (cfPWV) was found to be the most prominent variable for predicting overall cardiovascular risk. Cardiovascular risk is the overall risk to have any cardiovascular disease and it also pertains to the risk of cardiovascular mortality.
cfPWV has essential reliability and reproducibility with competent guidelines, devices and standardization process in place. However, the standardization still needs further efforts for effective and comparable widespread clinical use. The need for standardization is mainly caused by the fact that the methods and devices are still not uniformly used.
Utilization of pulse wave analysis variables for improving the diagnosis of peripheral artery disease specifically was found to be worthwhile but further studies are still needed. One important aspect related to this is that until these methods are included into peripheral artery disease guidelines, there is no relevant clinical benefit available from them.
As a whole, pulse wave analysis methods are intensively studied as a tool for diagnosis, but the varieties in measurement and on analysis methods at clinical circumstances as well as lack of validation continue to be major obstacles that prevent these methods from breaking through.
Kokoelmat
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