Moisture absorptivity of the poly(lactide-co-glycolide), and comparison of dehumidifying gases
Ala-Vannesluoma, Pauliina (2016)
Ala-Vannesluoma, Pauliina
2016
Biotekniikan koulutusohjelma
Luonnontieteiden tiedekunta - Faculty of Natural Sciences
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Hyväksymispäivämäärä
2016-06-08
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tty-201605184006
https://urn.fi/URN:NBN:fi:tty-201605184006
Tiivistelmä
The potential of the biodegradable polymers have been realized in the orthopedic and cosmetic applications world, due to their remarkable ability to degrade in vivo, why there is no need for second surgery. Poly(lactide-co-glycolide) (PLGA) is one of the most studied and used biodegradable polymer in orthopedic field, and the aim of this study was to examine the water absorption rate of PLGA (according to ISO62:2008), and comparing different dehumidifying gases for the drying processes.
The average absorption rate of the material was calculated to be for the process phase 2 samples 2.18 m-% and for the process phase 1 samples 0.51 m-% during 24 hours, in 100 % RH and at 23℃. In 50 % RH conditions the process phase 2 samples absorbed 0.74 m-% and for the process phase 1 samples 0.17 m-% during 24 hours. Since the production has under 50 % RH conditions, there should not be occurring any major degradation in these temperature values.
According to the directional tests that had done, compressed dry air (CDA) could be potential alternative for the nitrogen gas in drying and preservating processes, since its capability to preserve moisture content of the samples was relatively similar to nitrogen. However, some advantages were noticed compared to nitrogen, such as, more efficient water removal capability of the CDA, due to reactivity of oxygen with the water molecules.
The average absorption rate of the material was calculated to be for the process phase 2 samples 2.18 m-% and for the process phase 1 samples 0.51 m-% during 24 hours, in 100 % RH and at 23℃. In 50 % RH conditions the process phase 2 samples absorbed 0.74 m-% and for the process phase 1 samples 0.17 m-% during 24 hours. Since the production has under 50 % RH conditions, there should not be occurring any major degradation in these temperature values.
According to the directional tests that had done, compressed dry air (CDA) could be potential alternative for the nitrogen gas in drying and preservating processes, since its capability to preserve moisture content of the samples was relatively similar to nitrogen. However, some advantages were noticed compared to nitrogen, such as, more efficient water removal capability of the CDA, due to reactivity of oxygen with the water molecules.