MARK-AGE biomarkers of ageing
Bürkle, Alexander; Moreno-Villanueva, María; Bernhard, Jürgen; Hervonen, Antti; Hurme, Mikko (2015)
Hurme, Mikkoet al.
Mechanisms of Ageing and Development 151
Lääketieteen yksikkö - School of Medicine
Terveystieteiden yksikkö - School of Health Sciences
Julkaisun pysyvä osoite on
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
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