Properties of taurine release in glucose-free media in hippocampal slices from developing and adult mice
Oja, Simo; Saransaari, Pirjo (2015)
Oja, Simo
Saransaari, Pirjo
2015
Journal of Amino Acids 2015
254583
CC BY 3.0
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:uta-201610122430
https://urn.fi/URN:NBN:fi:uta-201610122430
Kuvaus
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Tiivistelmä
The release of preloaded [(3)H]taurine from hippocampal slices from developing 7-day-old and young adult 3-month-old mice was studied in a superfusion system in the absence of glucose. These hypoglycemic conditions enhanced the release at both ages, the effect being markedly greater in developing mice. A depolarizing K(+) concentration accentuated the release, which indicates that it was partially mediated by exocytosis. The anion channel blockers were inhibitory, witnessing the contribution of ion channels. NO-generating agents fomented the release as a sign of the participation of excitatory amino acid receptors. The other second messenger systems were apparently less efficient. The much greater taurine release could be a reason for the well-known greater tolerance of developing nervous tissue to lack of glucose.
Kokoelmat
- Artikkelit [6140]