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Horizontal transfer of β-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes

Emameh, Reza Zolfaghari; Barker, Harlan R; Tolvanen, Martti E E; Parkkila, Seppo; Hytönen, Vesa P (2016)

 
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Emameh, Reza Zolfaghari
Barker, Harlan R
Tolvanen, Martti E E
Parkkila, Seppo
Hytönen, Vesa P
2016

Parasites & vectors 9
152
BioMediTech - BioMediTech
Lääketieteen yksikkö - School of Medicine
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
doi:10.1186/s13071-016-1415-7
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Julkaisun pysyvä osoite on
http://urn.fi/URN:NBN:fi:uta-201604281493

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BioMed Central open access
Tiivistelmä
Background
Horizontal gene transfer (HGT) is a movement of genetic information occurring outside of normal mating activities. It is especially common between prokaryotic endosymbionts and their protozoan, insect, and nematode hosts. Although beta carbonic anhydrase (β-CA) plays a crucial role in metabolic functions of many living organisms, the origin of β-CA genes in eukaryotic species remains unclear.
Methods
This study was conducted using phylogenetics, prediction of subcellular localization, and identification of β-CA, transposase, integrase, and resolvase genes on the MGEs of bacteria. We also structurally analyzed β-CAs from protozoans, insects, and nematodes and their putative prokaryotic common ancestors, by homology modelling.
Results
Our investigations of a number of target genomes revealed that genes coding for transposase, integrase, resolvase, and conjugation complex proteins have been integrated with β-CA gene sequences on mobile genetic elements (MGEs) which have facilitated the mobility of β-CA genes from bacteria to protozoan, insect, and nematode species. The prokaryotic origin of protozoan, insect, and nematode β-CA enzymes is supported by phylogenetic analyses, prediction of subcellular localization, and homology modelling.
Conclusion
MGEs form a complete set of enzymatic tools, which are relevant to HGT of β-CA gene sequences from prokaryotes to protozoans, insects, and nematodes.
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Kalevantie 5
PL 617
33014 Tampereen yliopisto
oa[@]tuni.fi | Yhteydenotto | Tietosuoja | Saavutettavuusseloste