Relationship between the rate of gestational weight gain and overweight in offspring at the age of 3 years
KHAN, WAGMA (2012)
2012
Kansanterveystiede - Public Health
Terveystieteiden yksikkö - School of Health Sciences
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Hyväksymispäivämäärä
2012-05-08
Julkaisun pysyvä osoite on
https://urn.fi/urn:nbn:fi:uta-1-22405
https://urn.fi/urn:nbn:fi:uta-1-22405
Tiivistelmä
Objective: To assess the relationship between maternal weight gain during pregnancy and overweight including obesity in 3-year-old offspring.
Methods: The present study comprised 3916 children born between 1997-2004 in Pirkanmaa, southern Finland, with increased HLA-conferred susceptibility to type 1 diabetes. Information on both maternal anthropometries at first and last antenatal visit and BMI (body mass index) in the offspring at 3 years of age was available for 2143 mother-singleton child pairs. Rate of gestational weight gain was calculated as [(weight at last – weight at first antenatal visit) /number of weeks between the visits] and divided into quarters. Childhood overweight (obesity included) was defined according to IOTF (International Obesity Task Force) criteria for BMI. Logistic regression was used to study the relationship of rate of gestational weight gain and potential confounders to child overweight.
Results: Prevalence of overweight was higher in girls (14.6%) than in boys (7.8%), p= <0.001. Risk of child overweight was increased for both the highest [unadjusted OR 2.11 (95% CI 1.50-2.98)] and the lowest [unadjusted OR 1.47 (95% CI 1.01-2.15)] quarter of rate of gestational weight gain, compared to the middle two quarters. After adjustment for maternal BMI, level of education, smoking during pregnancy and gestational diabetes; sex, birth weight and gestational age of the child; duration of exclusive breast feeding; location of residence and paternal diabetes, the risk was statistically significantly increased in the lowest quarter [OR 1.73 (1.17-2.55)] of gestational weight gain. We did not observe any effect modification of the association by maternal BMI (interaction p=0.22).
Conclusion: Compared to the average rate of gestational weight gain, the lowest rate of weight gain placed the offspring at increased risk of overweight at 3 years of age.
Asiasanat:gestational weight gain, pregnancy weight gain, body mass index, overweight, obesity, children, offspring
Methods: The present study comprised 3916 children born between 1997-2004 in Pirkanmaa, southern Finland, with increased HLA-conferred susceptibility to type 1 diabetes. Information on both maternal anthropometries at first and last antenatal visit and BMI (body mass index) in the offspring at 3 years of age was available for 2143 mother-singleton child pairs. Rate of gestational weight gain was calculated as [(weight at last – weight at first antenatal visit) /number of weeks between the visits] and divided into quarters. Childhood overweight (obesity included) was defined according to IOTF (International Obesity Task Force) criteria for BMI. Logistic regression was used to study the relationship of rate of gestational weight gain and potential confounders to child overweight.
Results: Prevalence of overweight was higher in girls (14.6%) than in boys (7.8%), p= <0.001. Risk of child overweight was increased for both the highest [unadjusted OR 2.11 (95% CI 1.50-2.98)] and the lowest [unadjusted OR 1.47 (95% CI 1.01-2.15)] quarter of rate of gestational weight gain, compared to the middle two quarters. After adjustment for maternal BMI, level of education, smoking during pregnancy and gestational diabetes; sex, birth weight and gestational age of the child; duration of exclusive breast feeding; location of residence and paternal diabetes, the risk was statistically significantly increased in the lowest quarter [OR 1.73 (1.17-2.55)] of gestational weight gain. We did not observe any effect modification of the association by maternal BMI (interaction p=0.22).
Conclusion: Compared to the average rate of gestational weight gain, the lowest rate of weight gain placed the offspring at increased risk of overweight at 3 years of age.
Asiasanat:gestational weight gain, pregnancy weight gain, body mass index, overweight, obesity, children, offspring