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Non-Hodgkin lymphoma response evaluation with MRI texture classification

Pertovaara, Hannu; Heinonen, Tomi T; Järvenpää, Ritva; Harrison, Lara CV (Tay); Luukkaala, Tiina (Tay); Saarinen, Tuomas O (Tay); Soimakallio, Seppo (Tay); Kellokumpu-Lehtinen, Pirkko-Liisa (Tay); Dastidar, Prasun (Tay) (2009)

 
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Pertovaara, Hannu
Heinonen, Tomi T
Järvenpää, Ritva
Harrison, Lara CV (Tay)
Luukkaala, Tiina (Tay)
Saarinen, Tuomas O (Tay)
Soimakallio, Seppo (Tay)
Kellokumpu-Lehtinen, Pirkko-Liisa (Tay)
Dastidar, Prasun (Tay)
2009

Journal of Experimental & Clinical Cancer Research 28
87
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
doi:10.1186/1756-9966-28-87
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Julkaisun pysyvä osoite on
https://urn.fi/urn:nbn:uta-3-551

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BioMed Central Open access
Tiivistelmä
Background

To show magnetic resonance imaging (MRI) texture appearance change in non-Hodgkin lymphoma (NHL) during treatment with response controlled by quantitative volume analysis.

Methods

A total of 19 patients having NHL with an evaluable lymphoma lesion were scanned at three imaging timepoints with 1.5T device during clinical treatment evaluation. Texture characteristics of images were analyzed and classified with MaZda application and statistical tests.

Results

NHL tissue MRI texture imaged before treatment and under chemotherapy was classified within several subgroups, showing best discrimination with 96% correct classification in non-linear discriminant analysis of T2-weighted images.

Texture parameters of MRI data were successfully tested with statistical tests to assess the impact of the separability of the parameters in evaluating chemotherapy response in lymphoma tissue.

Conclusion

Texture characteristics of MRI data were classified successfully; this proved texture analysis to be potential quantitative means of representing lymphoma tissue changes during chemotherapy response monitoring.
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Kalevantie 5
PL 617
33014 Tampereen yliopisto
oa[@]tuni.fi | Tietosuoja | Saavutettavuusseloste
 

 

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Kalevantie 5
PL 617
33014 Tampereen yliopisto
oa[@]tuni.fi | Tietosuoja | Saavutettavuusseloste