Antibody to P.falciparum in Pregnancy Varies with Intermittent Preventive Treatment Regime and Bed Net Use
Aitken, Elizabeth; Mbewe, Bernard; Luntamo, Mari; Kulmala, Teija; Beeson, James; Ashorn, Per; Rogerson, Stephen (2012)
2012
Plos ONE 7 1
1-4
Lääketieteen yksikkö - School of Medicine
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Julkaisun pysyvä osoite on
http://urn.fi/urn:nbn:uta-3-956
http://urn.fi/urn:nbn:uta-3-956
Kuvaus
Public Library of Science
Tiivistelmä
Background
Antibodies towards placental-binding P. falciparum are thought to protect against pregnancy malaria; however, environmental factors may affect antibody development. Methods and Findings: Using plasma from pregnant Malawian women, we measured IgG against placental-binding P. falciparum parasites by flow cytometry, and related results to intermittent preventive treatment (IPTp) regime, and bed net use. Bed net use was associated with decreased antibody levels at mid-pregnancy but not at 1 month post partum (1 mpp). At 1 mpp a more intensive IPTp regime was associated with decreased antibody levels in primigravidae, but not multigravidae.
Conclusions/Significance
Results suggest bed nets and IPTp regime influence acquisition of pregnancy-specific P. falciparum immunity.
Antibodies towards placental-binding P. falciparum are thought to protect against pregnancy malaria; however, environmental factors may affect antibody development. Methods and Findings: Using plasma from pregnant Malawian women, we measured IgG against placental-binding P. falciparum parasites by flow cytometry, and related results to intermittent preventive treatment (IPTp) regime, and bed net use. Bed net use was associated with decreased antibody levels at mid-pregnancy but not at 1 month post partum (1 mpp). At 1 mpp a more intensive IPTp regime was associated with decreased antibody levels in primigravidae, but not multigravidae.
Conclusions/Significance
Results suggest bed nets and IPTp regime influence acquisition of pregnancy-specific P. falciparum immunity.
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