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Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age

Elfving, Maria; Svensson, Johan; Oikarinen, Sami; Jonsson, Björn; Olofsson, Per; Sundkvist, Göran; Lindberg, Bengt; Lernmark, Åke; Hyöty, Heikki; Ivarsson, Sten-Anders (2008)

 
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Elfving, Maria
Svensson, Johan
Oikarinen, Sami
Jonsson, Björn
Olofsson, Per
Sundkvist, Göran
Lindberg, Bengt
Lernmark, Åke
Hyöty, Heikki
Ivarsson, Sten-Anders
2008

Experimental Diabetes Research 2008
271958
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
doi:10.1155/2008/271958
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Julkaisun pysyvä osoite on
https://urn.fi/urn:nbn:uta-3-724

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Hindawi Open access
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Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring’s risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulinM(IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22– 17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.
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Kalevantie 5
PL 617
33014 Tampereen yliopisto
oa[@]tuni.fi | Yhteydenotto | Tietosuoja | Saavutettavuusseloste