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Lipoprotein docosapentaenoic acid is associated with serum matrix metalloproteinase-9 concentration

Solakivi, Tiina; Jaakkola, Olli; Kalela, Anne; Pispa, Mari; Salomäki, Anne; Lehtimäki, Terho; Höyhtyä, Matti; Jokela, Hannu; Nikkari, Seppo T (2005)

 
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lipoprotein_docosapentaenoic_acid_2005.pdf (263.8Kt)
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Solakivi, Tiina
Jaakkola, Olli
Kalela, Anne
Pispa, Mari
Salomäki, Anne
Lehtimäki, Terho
Höyhtyä, Matti
Jokela, Hannu
Nikkari, Seppo T
2005

Lipids in Health and Disease 4
8
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
doi:10.1186/1476-511X-4-8
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Julkaisun pysyvä osoite on
https://urn.fi/urn:nbn:uta-3-645

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BioMed Central Open access
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Background

Polyunsaturated fatty acids (PUFA) are thought to play important roles in inflammation. The n-3 series is considered as anti-inflammatory, and some studies have reported increased plasma n-3 polyunsaturated fatty acid pattern in chronic inflammatory conditions. In this study we sought to clarify relationships of the levels of arachidonic acid and the polyunsaturated n-3 fatty acid compositions of isolated LDL, HDL2 and HDL3 particles with matrix metalloproteinase-9 (MMP-9), a marker of inflammation.

Results

The subjects were divided into two groups: those with lower and those with higher than the median serum MMP-9 concentration. In all lipoprotein fractions, the mean percentage of docosapentaenoic acid (C22:5n-3) was higher in the group of subjects with higher MMP-9 level than in those with lower serum MMP-9 concentration (P < 0.01 for all). Likewise, the ratio of docosapentaenoic acid to arachidonic acid (C20:4n-6) was higher in the subjects with higher MMP-9 compared with the lower MMP-9 group (P < 0.001 for all).

Conclusion

So far, the evidence for an anti-inflammatory role of the n-3 PUFA has come from dietary interventions. Our results were obtained from a free-living population and indicate that there is a positive correlation between n-3 docosapentaenoic acid and MMP-9. What had triggered the rise in MMP-9 is not known, since serum level of MMP-9 is raised in many inflammatory conditions. These findings may indicate an increased biosynthesis of n-3 polyunsaturated fatty acids in subclinical inflammation.
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Kalevantie 5
PL 617
33014 Tampereen yliopisto
oa[@]tuni.fi | Tietosuoja | Saavutettavuusseloste