Hyppää sisältöön
    • Suomeksi
    • In English
Trepo
  • Suomeksi
  • In English
  • Kirjaudu
Näytä viite 
  •   Etusivu
  • Trepo
  • Artikkelit
  • Näytä viite
  •   Etusivu
  • Trepo
  • Artikkelit
  • Näytä viite
JavaScript is disabled for your browser. Some features of this site may not work without it.

Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa

Kummola, Laura; Hämäläinen, Jonna M; Kivelä, Jyrki; Kivelä, Antti J; Saarnio, Juha; Karttunen, Tuomo; Parkkila, Seppo (2005)

 
Avaa tiedosto
expression_of_novel_2005.pdf (1.132Mt)
Lataukset: 



Kummola, Laura
Hämäläinen, Jonna M
Kivelä, Jyrki
Kivelä, Antti J
Saarnio, Juha
Karttunen, Tuomo
Parkkila, Seppo
2005

BMC Cancer 5
41
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
doi:10.1186/1471-2407-5-41
Näytä kaikki kuvailutiedot
Julkaisun pysyvä osoite on
https://urn.fi/urn:nbn:uta-3-644

Kuvaus

BioMed Central Open access
Tiivistelmä
Background

Carbonic anhydrase (CA) isozymes may have an important role in cancer development. Some isozymes control pH homeostasis in tumors that appears to modulate the behaviour of cancer cells. CA XIII is the newest member of the CA gene family. It is a cytosolic isozyme which is expressed in a number of normal tissues. The present study was designed to investigate CA XIII expression in prospectively collected colorectal tumor samples.

Methods

Both neoplastic and normal tissue specimens were obtained from the same patients. The analyses were performed using CA XIII-specific antibodies and an immunohistochemical staining method. For comparison, the tissue sections were immunostained for other cytosolic isozymes, CA I and II.

Results

The results indicated that the expression of CA XIII is down-regulated in tumor cells compared to the normal tissue. The lowest signal was detected in carcinoma samples. This pattern of expression was quite parallel for CA I and II.

Conclusion

The down-regulation of cytosolic CA I, II and XIII in colorectal cancer may result from reduced levels of a common transcription factor or loss of closely linked CA1, CA2 and CA13 alleles on chromosome 8. Their possible role as tumor suppressors should be further evaluated.
Kokoelmat
  • Artikkelit [6122]
Kalevantie 5
PL 617
33014 Tampereen yliopisto
oa[@]tuni.fi | Tietosuoja | Saavutettavuusseloste
 

 

Selaa kokoelmaa

TekijätNimekkeetTiedekunta (2019 -)Tiedekunta (- 2018)Tutkinto-ohjelmat ja opintosuunnatAvainsanatJulkaisuajatKokoelmat

Omat tiedot

Kirjaudu sisäänRekisteröidy
Kalevantie 5
PL 617
33014 Tampereen yliopisto
oa[@]tuni.fi | Tietosuoja | Saavutettavuusseloste