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Carbonic anhydrase IX in oligodendroglial brain tumors

Järvelä, Sally; Parkkila, Seppo; Bragge, Helena; Kähkönen, Marketta; Parkkila, Anna-Kaisa; Soini, Ylermi; Pastorekova, Silvia; Pastorek, Jaromir; Haapasalo, Hannu (2008)

 
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carbonic_anhydrase_IX_in oligodendroglial_2008.pdf (868.7Kt)
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Järvelä, Sally
Parkkila, Seppo
Bragge, Helena
Kähkönen, Marketta
Parkkila, Anna-Kaisa
Soini, Ylermi
Pastorekova, Silvia
Pastorek, Jaromir
Haapasalo, Hannu
2008

BMC Cancer 8
1
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
doi:10.1186/1471-2407-8-1
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Julkaisun pysyvä osoite on
https://urn.fi/urn:nbn:uta-3-589

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BioMed Central Open access
Tiivistelmä
Background

Carbonic anhydrase IX is a hypoxia-induced enzyme that has many biologically important functions, including its role in cell adhesion and invasion.

Methods

This study was set out to investigate the role of CA IX in a series of 86 oligodendroglial brain tumors (71 primary and 15 recurrent; 48 pure oligodendrogliomas and 40 mixed oligoastrocytomas).

Results

80% of the tumors showed CA IX expression by immunohistochemistry. Tumors with moderate or strong CA IX expression had decreased level of cell proliferation compared to weak or no CA IX expression (median 2.9 vs. 5.8, p = 0.015). CA IX correlated with two antioxidative enzymes, manganese superoxide dismutase (MnSOD) and regulatory gammaglutamylcysteine synthetase (GLCL-R): CA IX expression was significantly higher in MnSOD-positive tumors (p = 0.008) and decreased in GLCL-R-positive tumors (p = 0.044). In Cox multivariate analysis CA IX expression, patient age and histological component (pure oligodendroglioma vs. mixed oligoastrocytoma) showed independent prognostic values (p = 0.009, p = 0.003 and p = 0.022, respectively), CA IX positivity predicting poorer outcome.

Conclusion

CA IX was proved to be an independent prognostic indicator in oligodendroglial brain tumors, and it also correlates reversely with cell proliferation. It may have a role in the biology of oligodendrogliomas, and most interestingly, as it is mainly expressed in tumor tissue, CA IX could serve as a target molecule for anticancer treatments.
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Kalevantie 5
PL 617
33014 Tampereen yliopisto
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