Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study
Service, Helena M; Hintsanen, Mirka; Hintsa, Taina; Lehtimäki, Terho; Raitakari, Olli T; Viikari, Jorma S; Keltikangas-Järvinen, Liisa (2008)
2008
Behavioral and Brain Functions 4
40
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
Julkaisun pysyvä osoite on
https://urn.fi/urn:nbn:uta-3-565
https://urn.fi/urn:nbn:uta-3-565
Kuvaus
BioMed Central Open access
Tiivistelmä
Background
Neuregulin-1 proteins are related to physiological correlates of Type A in terms of cardiac reactivity. Furthermore, neuregulin-1 gene (NRG1) may play a role in cardiovascular disease such as atherosclerosis and coronary heart disease i.e. the suggested "outcomes" of Type A behavior. Therefore, NRG1 is hypothesized to be associated with Type A behavior.
Methods
The study examined whether Type A behavior pattern is associated with the single nucleotide polymorphism (SNP) SNP8NRG221533 of the NRG1. The subjects were 631 men and women participating in the population-based Cardiovascular Risk in Young Finns study in 1992 and 2001. Type A was self-assessed with the Framingham Type A Scale and reassessed nine years later.
Results
Type A was associated with NRG1 genotype. Carriers of genotype CC scored lower on Type A compared to the others.
Conclusion
Our study has pinpointed a SNP in NRG1 that predicts Type A behavior. As previous evidence suggests an association for NRG1 with beta-adrenergic stimulation, its role underlying Type A is discussed.
Neuregulin-1 proteins are related to physiological correlates of Type A in terms of cardiac reactivity. Furthermore, neuregulin-1 gene (NRG1) may play a role in cardiovascular disease such as atherosclerosis and coronary heart disease i.e. the suggested "outcomes" of Type A behavior. Therefore, NRG1 is hypothesized to be associated with Type A behavior.
Methods
The study examined whether Type A behavior pattern is associated with the single nucleotide polymorphism (SNP) SNP8NRG221533 of the NRG1. The subjects were 631 men and women participating in the population-based Cardiovascular Risk in Young Finns study in 1992 and 2001. Type A was self-assessed with the Framingham Type A Scale and reassessed nine years later.
Results
Type A was associated with NRG1 genotype. Carriers of genotype CC scored lower on Type A compared to the others.
Conclusion
Our study has pinpointed a SNP in NRG1 that predicts Type A behavior. As previous evidence suggests an association for NRG1 with beta-adrenergic stimulation, its role underlying Type A is discussed.
Kokoelmat
- Artikkelit [6140]