Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903-induced Skin Inflammation
González-Rodríguez, Martín I.; Salomaa, Tanja; Cabalin, Carolina; Komulainen, Tuomas; Hiihtola, Lotta; Kummola, Laura; Järvinen, Tero A.H.; Junttila, Ilkka S. (2026-04)
Avaa tiedosto
Lataukset:
González-Rodríguez, Martín I.
Salomaa, Tanja
Cabalin, Carolina
Komulainen, Tuomas
Hiihtola, Lotta
Kummola, Laura
Järvinen, Tero A.H.
Junttila, Ilkka S.
04 / 2026
European Journal of Immunology
e70178
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202606046950
https://urn.fi/URN:NBN:fi:tuni-202606046950
Kuvaus
Non peer reviewed
Tiivistelmä
Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 needed for TSLP signaling has been unclear. We found that LCs express both receptor chains needed by TSLP (CD127 and TSLPR) and upregulate the TSLPR upon Calcipotriol (MC903)-induced inflammation.
Kokoelmat
- TUNICRIS-julkaisut [25372]
