Prevalence of Eye Diseases in a Multiple Sclerosis Cohort
Valpas, Jesse (2026)
2026
Lääketieteen lisensiaatin tutkinto-ohjelma - Licentiate's Programme in Medicine
Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology
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Hyväksymispäivämäärä
2026-04-27
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202604274365
https://urn.fi/URN:NBN:fi:tuni-202604274365
Tiivistelmä
Introduction: Multiple sclerosis (MS) is a disorder causing central nervous system demyelination, often affecting multiple functions, including vision. This study focuses on eye diseases in the MS cohort. The aim was to find out the occurrence of different ocular diseases.
Methods: The cohort included 344 Finnish participants (men=79 and women=259) from 18 to 60 years old from Pirkanmaa Hospital district. Cohort data was obtained from Finland's national MS register. Participants' eyes were examined by eye specialists, visual acuity was measured and data including history of ocular diseases was collected.
Results: Different ocular diseases were identified, in total 49, but the most relevant were: optic neuritis (42,5%), uveitis (11,5%), cataracts (3,5%) glaucoma (0,9%), ocular nerve palsies and INO (4,7%). Visual acuity average was 1.02 (95% CI, 1.00-1.03), for participants that did not have optic neuritis average was 1.05 and Cl (95% CI, 1.03-1.06) and participants with history of optic neuritis average was 0.97 (95% CI; 0.95-1.00).
Discussion: Visual acuity was found to be within normal ranges in participants with it being lower in participants that had had optic neuritis previously. Optic neuritis is important to consider in MS populations. This study also found that uveitis, INO and oculomotor nerve palsies are more common in individuals with MS when compared to the general population. The eyes of individuals with MS should be examined with a low threshold if symptoms arise.
Methods: The cohort included 344 Finnish participants (men=79 and women=259) from 18 to 60 years old from Pirkanmaa Hospital district. Cohort data was obtained from Finland's national MS register. Participants' eyes were examined by eye specialists, visual acuity was measured and data including history of ocular diseases was collected.
Results: Different ocular diseases were identified, in total 49, but the most relevant were: optic neuritis (42,5%), uveitis (11,5%), cataracts (3,5%) glaucoma (0,9%), ocular nerve palsies and INO (4,7%). Visual acuity average was 1.02 (95% CI, 1.00-1.03), for participants that did not have optic neuritis average was 1.05 and Cl (95% CI, 1.03-1.06) and participants with history of optic neuritis average was 0.97 (95% CI; 0.95-1.00).
Discussion: Visual acuity was found to be within normal ranges in participants with it being lower in participants that had had optic neuritis previously. Optic neuritis is important to consider in MS populations. This study also found that uveitis, INO and oculomotor nerve palsies are more common in individuals with MS when compared to the general population. The eyes of individuals with MS should be examined with a low threshold if symptoms arise.