An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels

Samanta, Sumanta; Rangasami, Vignesh K.; Murugan, N. Arul; Parihar, Vijay Singh; Varghese, Oommen P.; Oommen, Oommen P. (2021)
 
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Samanta, Sumanta
Rangasami, Vignesh K.
Murugan, N. Arul
Parihar, Vijay Singh
Varghese, Oommen P.
Oommen, Oommen P.
2021

Polymer Chemistry
doi:10.1039/d1py00013f
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https://urn.fi/URN:NBN:fi:tuni-202106185977

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<p>We present here a new insight into the chemical reactivity and bioactivity of dopamine (DA) and gallic acid (GA) and their hyaluronic acid (HA) conjugates. Our data suggest that HA-GA scaffolds are superior to HA-DA, with higher oxidation kinetics, improved tissue adhesive properties, and radical scavenging ability with a lower pro-inflammatory response. This journal is </p>
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