Mechanical characterization of pore-graded bioactive glass scaffolds produced by robocasting

Abstract

<p>Since the discovery of 45S5 Bioglass<sup>®</sup> by Larry Hench, bioactive glasses have been widely studied as bone substitute materials and, in more recent years, have also shown great promise for producing three-dimensional scaffolds. The development of additive manufacturing techniques and their application in bone tissue engineering allows the design and fabrication of complex structures with controlled porosity. However, achieving strong and mechanically-reliable bioactive glass scaffolds is still a great challenge. Furthermore, there is a relative paucity of studies reporting an exhaustive assessment of other mechanical properties than compressive strength of glass-derived scaffolds. This research work aimed at determining key mechanical properties of silicate SiO<sub>2</sub>-Na<sub>2</sub>O-K<sub>2</sub>OMgO-CaO-P<sub>2</sub>O<sub>5</sub> glass scaffolds fabricated by robocasting and exhibiting a porosity gradient. When tested in compression, these scaffolds had a strength of 6 MPa, a Young's modulus around 340 MPa, a fracture energy of 93 kJ/m<sup>3</sup> and a Weibull modulus of 3, which provides a quantification of the scaffold reliability and reproducibility. Robocasting was a suitable manufacturing method to obtain structures with favorable porosity and mechanical properties comparable to those of the human cancellous bone, which is fundamental regarding osteointegration of bone implants.</p>