Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes

Taka, Antti Mathias; But, Anna; Lempainen, Johanna; Vatanen, Tommi; Härkönen, Taina; Ilonen, Jorma; Knip, Mikael (2023-03)
 
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Taka, Antti Mathias
But, Anna
Lempainen, Johanna
Vatanen, Tommi
Härkönen, Taina
Ilonen, Jorma
Knip, Mikael
03 / 2023

DIABETES RESEARCH AND CLINICAL PRACTICE
110256
doi:10.1016/j.diabres.2023.110256
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https://urn.fi/URN:NBN:fi:tuni-202307067132

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The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk genotype have a 45-fold disease risk compared to peers with neutral or protective genotypes.
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