Clinical Outcomes After Revision Hip Arthroplasty due to Prosthetic Joint Infection - A Single-Center Study of 369 Hips at a High-Volume Center with a Minimum of One Year Follow-up

Abstract

<p>BACKGROUND: Prosthetic joint infection (PJI) treatment decisions are traditionally based on treatment algorithms. There is, however, a lack of evidence to support the choice of these treatment algorithms. Therefore, we aimed to assess the one-year survival after PJI revision and compared different surgical strategies in a single-center setting.</p><p>METHODS: Revisions of the hip due to PJI performed at our institution between January 2008 and September 2021 with at least one-year of follow-up were identified. In total, 134 debridement, antibiotics, and implant retentions (DAIRs), 114 one-stage revisions, and 121 two-stage revisions were performed. Infections were classified as early, acute hematogenous, and chronic. Survival was calculated using the Kaplan-Meier method and cumulative incidence function. Predictors of outcomes were examined with Fine-Gray regressions and Cox proportional hazards regressions. Subdistribution hazard ratios and hazard ratios (HR) with 95% confidence intervals (CIs) were calculated.</p><p>RESULTS: At one-year follow-up, 26.6% (CI 22.2-31.2%) of the patients had undergone reoperation and 7.9% (CI 5.4-10.9%) had died. The risk for reoperation was highest after DAIR (36.6%, CI 28.5-44.7%) and lowest after one-stage revision (20.2%, CI 13.4-28%). Within the early infections, the one-stage revision almost halved the risk of reoperation (HR 0.51, CI 0.31-0.84) with no added mortality risk (HR 1.05, CI 0.5-2.2), when compared to DAIR.</p><p>CONCLUSION: By utilizing 1-stage revision over DAIR in early infections, it might be possible to improve the prognosis by decreasing the risk of reoperation without increasing mortality. However, as the patient selection is undeniably difficult, more research is warranted.</p>