An ancestral molecular response to nanomaterial particulates

del Giudice, G.; Serra, A.; Saarimäki, L. A.; Kotsis, K.; Rouse, I.; Colibaba, S. A.; Jagiello, K.; Mikolajczyk, A.; Fratello, M.; Papadiamantis, A. G.; Sanabria, N.; Annala, M. E.; Morikka, J.; Kinaret, P. A.S.; Voyiatzis, E.; Melagraki, G.; Afantitis, A.; Tämm, K.; Puzyn, T.; Gulumian, M.; Lobaskin, V.; Lynch, I.; Federico, A.; Greco, D. (2023)
 
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del Giudice, G.
Serra, A.
Saarimäki, L. A.
Kotsis, K.
Rouse, I.
Colibaba, S. A.
Jagiello, K.
Mikolajczyk, A.
Fratello, M.
Papadiamantis, A. G.
Sanabria, N.
Annala, M. E.
Morikka, J.
Kinaret, P. A.S.
Voyiatzis, E.
Melagraki, G.
Afantitis, A.
Tämm, K.
Puzyn, T.
Gulumian, M.
Lobaskin, V.
Lynch, I.
Federico, A.
Greco, D.
2023

Nature Nanotechnology
doi:10.1038/s41565-023-01393-4
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202309057948

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Peer reviewed
Tiivistelmä
The varied transcriptomic response to nanoparticles has hampered the understanding of the mechanism of action. Here, by performing a meta-analysis of a large collection of transcriptomics data from various engineered nanoparticle exposure studies, we identify common patterns of gene regulation that impact the transcriptomic response. Analysis identifies deregulation of immune functions as a prominent response across different exposure studies. Looking at the promoter regions of these genes, a set of binding sites for zinc finger transcription factors C2H2, involved in cell stress responses, protein misfolding and chromatin remodelling and immunomodulation, is identified. The model can be used to explain the outcomes of mechanism of action and is observed across a range of species indicating this is a conserved part of the innate immune system.
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