Association of COVID-19 with neurological disorders: What do we know so far?
Haavisto, Peppi (2024)
2024
Bioteknologian ja biolääketieteen tekniikan kandidaattiohjelma - Bachelor's Programme in Biotechnology and Biomedical Engineering
Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology
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Hyväksymispäivämäärä
2024-04-26
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202404163581
https://urn.fi/URN:NBN:fi:tuni-202404163581
Tiivistelmä
The outbreak of severe acute respiratory syndrome coronavirus (SARS-CoV-2) causing COVID-19 led to a global pandemic. Infection with this virus has caused a range of symptoms from mild flu-like ailments to severe organ failures, cardiovascular issues, and gastrointestinal symptoms. Neurological symptoms associated with the virus and COVID-19 have garnered increasing attention.
This thesis aims to explore the link between SARS-CoV-2 and various neurological disorders to date, investigating potential pathogenic mechanisms and hypotheses regarding the viral role in predisposing individuals to specific neurological conditions. Acknowledging the impact SARS-CoV-2 has on the central nervous system is imperative to enhance the understanding of COVID-19’s neurological implications. Among the various neurological symptoms and disorders associated with SARS-CoV-2 infection, we have selected the following diseases based on their documented reports: Multiple sclerosis, Alzheimer's disease, Parkinson’s disease, Guillain-Barré syndrome, and epilepsy.
Several plausible factors link SARS-CoV-2 with the immunopathogeneses of neurological disorders, such as activated microglia, neuroinflammation, cytokine storm, oxidative stress, electrolyte imbalances, and disruptions to the blood-brain barrier and blood-nerve barrier. Virus receptors expressed in multiple neural cells facilitate viral intrusion. Additionally, similarities between SARS-CoV-2 and central nervous system proteins may trigger autoimmune responses.
The associations are complex and possibly bidirectional, although conclusive evidence is lacking in current research. Further investigation into pathogenic mechanisms and associations is essential for comprehending long-term consequences and utilizing that knowledge in disease prevention and management strategies.
This thesis aims to explore the link between SARS-CoV-2 and various neurological disorders to date, investigating potential pathogenic mechanisms and hypotheses regarding the viral role in predisposing individuals to specific neurological conditions. Acknowledging the impact SARS-CoV-2 has on the central nervous system is imperative to enhance the understanding of COVID-19’s neurological implications. Among the various neurological symptoms and disorders associated with SARS-CoV-2 infection, we have selected the following diseases based on their documented reports: Multiple sclerosis, Alzheimer's disease, Parkinson’s disease, Guillain-Barré syndrome, and epilepsy.
Several plausible factors link SARS-CoV-2 with the immunopathogeneses of neurological disorders, such as activated microglia, neuroinflammation, cytokine storm, oxidative stress, electrolyte imbalances, and disruptions to the blood-brain barrier and blood-nerve barrier. Virus receptors expressed in multiple neural cells facilitate viral intrusion. Additionally, similarities between SARS-CoV-2 and central nervous system proteins may trigger autoimmune responses.
The associations are complex and possibly bidirectional, although conclusive evidence is lacking in current research. Further investigation into pathogenic mechanisms and associations is essential for comprehending long-term consequences and utilizing that knowledge in disease prevention and management strategies.
Kokoelmat
- Kandidaatintutkielmat [10550]