Guidelines for clinicians and scientists to make most out of FinnGen genome and digital health care data - The FinnGen Analyst Handbook
Niemi, Marianna (2022)
Niemi, Marianna
2022
Master's Programme in Biomedical Technology
Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
Hyväksymispäivämäärä
2022-05-30
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202205104698
https://urn.fi/URN:NBN:fi:tuni-202205104698
Tiivistelmä
The FinnGen Analyst Handbook is an electronic guidebook aiming to provide FinnGen researchers with all the guidelines, knowledge, and helpful tips they need when analysing, interpreting, and making discoveries with the FinnGen data. FinnGen Analyst Handbook provides detailed instructions for conducting genome-wide association study (GWAS) and medical register-based analysis aiming to reveal associations between conditions and the genome.
FinnGen, started in 2017, is a public-private research project funded by Business Finland and 13 pharmaceutical companies. FinnGen’s host organization is the Institute for Molecular Medicine Finland, FIMM, University of Helsinki. The aim of FinnGen study is to improve human health through genetic research and lead to improvements in diagnostics and new therapeutic targets for treating numerous human diseases.
FinnGen project combines genome data from 500,000 Finnish biobank participants with a longitudinal lifetime spanning health registry data aiming to provide comprehensive data for research of various human diseases. By finding associations between genetic factors and health outcomes FinnGen project aims to provide novel medically and therapeutically relevant insights. Being one of the biggest Biobank projects worldwide FinnGen provides a world-class resource for future research.
This Master’s Thesis work was to write documentation for FinnGen Analyst Handbook. This thesis gives a report about the Analyst Handbook and its writing process. In addition, one example of the entire workflow for GWAS using Analyst Handbook instructions, FinnGen custom-made tools, and R coding is provided.
FinnGen, started in 2017, is a public-private research project funded by Business Finland and 13 pharmaceutical companies. FinnGen’s host organization is the Institute for Molecular Medicine Finland, FIMM, University of Helsinki. The aim of FinnGen study is to improve human health through genetic research and lead to improvements in diagnostics and new therapeutic targets for treating numerous human diseases.
FinnGen project combines genome data from 500,000 Finnish biobank participants with a longitudinal lifetime spanning health registry data aiming to provide comprehensive data for research of various human diseases. By finding associations between genetic factors and health outcomes FinnGen project aims to provide novel medically and therapeutically relevant insights. Being one of the biggest Biobank projects worldwide FinnGen provides a world-class resource for future research.
This Master’s Thesis work was to write documentation for FinnGen Analyst Handbook. This thesis gives a report about the Analyst Handbook and its writing process. In addition, one example of the entire workflow for GWAS using Analyst Handbook instructions, FinnGen custom-made tools, and R coding is provided.