Tissue engineering of human knee meniscus
Luojus, Matilda (2022)
Luojus, Matilda
2022
Bioteknologian ja biolääketieteen tekniikan kandidaattiohjelma - Bachelor's Programme in Biotechnology and Biomedical Engineering
Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology
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Hyväksymispäivämäärä
2022-05-20
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202205094578
https://urn.fi/URN:NBN:fi:tuni-202205094578
Tiivistelmä
The knee menisci are c-shaped fibrocartilaginous structures in the knee joint that have a crucial function in stabilization, shock absorption and load transmission. A knee has two menisci, medial on the inside and lateral on the outside. Meniscus lesions are common knee injuries that typically occur in the form of tears. Current clinical practice is based on removing either the whole meniscus or only a part of it, repairing the meniscus with the help of sutures, arrows, and screws, or utilizing meniscus reconstruction methods to replace the native meniscus. Due to the high incidence in the knee injuries and resulting expenses, tissue-engineered meniscus repair has become a widely investigated option.
Traditional meniscus tissue engineering is based on combining three-dimensional support structures called scaffolds, cells, and biochemical and mechanical stimulation to develop an ideal, biocompatible meniscus replacement. Besides scaffold-based approaches, scaffold-free tissue engineering, which does not utilize cell seeding or attachment within an exogenous material, has also gained interest lately.
The aim of this literature review is to get acquainted with the different tissue engineering applications related to meniscus. The current commercial applications and the possible applications for the human knee meniscus in the future are described. The contemporary scientific situation of the applications is also discovered, as well as the challenges and advantages related to the tissue engineering applications. This thesis demonstrates that promising meniscus-preserving and -replacing treatment options have been developed. However, additional research is still essential before the solutions can be commercialized.
Traditional meniscus tissue engineering is based on combining three-dimensional support structures called scaffolds, cells, and biochemical and mechanical stimulation to develop an ideal, biocompatible meniscus replacement. Besides scaffold-based approaches, scaffold-free tissue engineering, which does not utilize cell seeding or attachment within an exogenous material, has also gained interest lately.
The aim of this literature review is to get acquainted with the different tissue engineering applications related to meniscus. The current commercial applications and the possible applications for the human knee meniscus in the future are described. The contemporary scientific situation of the applications is also discovered, as well as the challenges and advantages related to the tissue engineering applications. This thesis demonstrates that promising meniscus-preserving and -replacing treatment options have been developed. However, additional research is still essential before the solutions can be commercialized.
Kokoelmat
- Kandidaatintutkielmat [8344]