Bacterial Cellulose as a Surgical Suture Material
Meriläinen, Ella (2021)
Meriläinen, Ella
2021
Bioteknologian ja biolääketieteen tekniikan kandidaattiohjelma - Bachelor's Programme in Biotechnology and Biomedical Engineering
Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology
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Hyväksymispäivämäärä
2021-06-08
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202105265471
https://urn.fi/URN:NBN:fi:tuni-202105265471
Tiivistelmä
Surgical sutures are used to approximate tissues together which enables the wound closure and healing. An ideal suture should have a good balance between the suture diameter and tensile strength and the surgeons should be able to handle the suture easily while making the stitches.
Bacterial cellulose (BC) is cellulose that is produced extracellularly by some bacteria. Although the BC and plant-based cellulose (PC) have the same molecular formula, their material properties are different. BC is an attractive biomaterial in the medical engineering field because it is very pure, has good biocompatibility, and it does not normally degrade in the body environment. The properties of BC can be changed for example via chemical modifications or changing the culture conditions. BC is a very versatile material which makes it an attractive material for surgical suture research.
This bachelor’s thesis aimed to study if BC can be used as surgical suture material and how this type of sutures could be produced. The goal was also to find out if the research results of the studies about the usage of PC in surgical sutures can be applied with BC. The research was done by using literature sources, like existing research and patent documents.
The findings of this thesis were able to answer all research questions. BC has been used as a surgical suture material in several studies with promising results but currently, there are no commercialized BC-based sutures in the market. Multiple ways to produce BC sutures were found, including wet-spinning, hydrogel strip cutting and cultivation form-based methods. Studies with PC were assumed to be appliable with BC in the cases where the PC was not used as a natural plant fibre structure. For example, studies with PC-based hydrogel sutures could be appliable with BC due to the similarities of their chemical structures.
Bacterial cellulose (BC) is cellulose that is produced extracellularly by some bacteria. Although the BC and plant-based cellulose (PC) have the same molecular formula, their material properties are different. BC is an attractive biomaterial in the medical engineering field because it is very pure, has good biocompatibility, and it does not normally degrade in the body environment. The properties of BC can be changed for example via chemical modifications or changing the culture conditions. BC is a very versatile material which makes it an attractive material for surgical suture research.
This bachelor’s thesis aimed to study if BC can be used as surgical suture material and how this type of sutures could be produced. The goal was also to find out if the research results of the studies about the usage of PC in surgical sutures can be applied with BC. The research was done by using literature sources, like existing research and patent documents.
The findings of this thesis were able to answer all research questions. BC has been used as a surgical suture material in several studies with promising results but currently, there are no commercialized BC-based sutures in the market. Multiple ways to produce BC sutures were found, including wet-spinning, hydrogel strip cutting and cultivation form-based methods. Studies with PC were assumed to be appliable with BC in the cases where the PC was not used as a natural plant fibre structure. For example, studies with PC-based hydrogel sutures could be appliable with BC due to the similarities of their chemical structures.
Kokoelmat
- Kandidaatintutkielmat [8798]