Trepo - Selaus asiasanan mukaan "1182"

Viitteet 1-20 / 177

    • 3D-printed β-TCP scaffold as a bone-mimicking environment for an engineered model of osteosarcoma: In vitro properties and transcriptomic insights 

      Menshikh, Ksenia; Gobbo, Virginia Alessandra; Nascimben, Mauro; Hannula, Markus; Cochis, Andrea; Serra, Tiziano; Massera, Jonathan; Pandit, Abhay; Rimondini, Lia (06 / 2025)
      article
      In the face of advancements in osteosarcoma research, existing preclinical models – including in vitro (i.e., two- and three-dimensional cell cultures, organoids) and in vivo approaches (i.e., xenografts, animal models) – ...

    • Absolute copy number aware CNV calling of sub-megabase segments in ultra-low coverage single-cell DNA sequencing data 

      Kolbeinsdottir, Solrun; Zachariadis, Vasilios; Sommerauer, Christian; Lohi, Olli; Heinäniemi, Merja; Enge, Martin (23.09.2025)
      article
      Recent advances in ultra-low coverage whole-genome sequencing (WGS) of single cells have enabled detailed analysis of copy number variation at a throughput approaching that of single-cell RNA sequencing. However, downstream ...

    • Accuracy of Intra-Axial Brain Tumor Characterization in the Emergency MRI Reports: A Retrospective Human Performance Benchmarking Pilot Study 

      Sirén, Aapo; Turkia, Elina; Nyman, Mikko; Hirvonen, Jussi (08 / 2024)
      article
      Demand for emergency neuroimaging is increasing. Even magnetic resonance imaging (MRI) is often performed outside office hours, sometimes revealing more uncommon entities like brain tumors. The scientific literature studying ...

    • Advanced deep learning approaches for the automated classification of macrofungal species in biodiversity monitoring 

      Özsarı, Şifa; Kumru, Eda; Ekinci, Fatih; Güzel, Mehmet Serdar; Açıcı, Koray; Aşuroğlu, Tunç; Akata, Ilgaz (15.10.2025)
      article
      Macrofungal species attract significant attention due to their critical roles in ecosystems and widespread industrial applications. Traditional species identification methods are expertise-intensive and time-consuming ...

    • Advances in mixed ligand transition metal complexes: Chromone derivatives and N, O donor ligands – a comprehensive review 

      Kolhe, Nitin H.; Tamboli, Yasinalli; Bawazir, Huda A.; Parihar, Vijay Singh (01.02.2025)
      reviewarticle
      Mixed-ligand transition metal complexes have emerged as a significant area of research due to their tunable structural, electronic, and biological properties. This comprehensive review provides a detailed analysis of recent ...

    • Age-related changes in cardiolipin profile and functional consequences of altered fatty acid supply 

      Weiß, Philipp W.; Kaltenborn, Philip P.; Frahm, Christiane; Schulze-Späte, Ulrike; Heyne, Estelle; Szibor, Marten; Nietzsche, Sandor; Claus, Ralf A.; Gräler, Markus H. (12 / 2025)
      article
      Cardiolipins (CLs) are primarily expressed in the inner mitochondrial membrane where they play essential roles in membrane architecture and mitochondrial functions. CLs have a unique structure characterized by four acyl ...

    • AI is a viable alternative to high throughput screening: a 318-target study 

      Wallach, Izhar; Bernard, Denzil; Nguyen, Kong; Ho, Gregory; Morrison, Adrian; Stecula, Adrian; Rosnik, Andreana; O’Sullivan, Ann Marie; Davtyan, Aram; Samudio, Ben; Thomas, Bill; Worley, Brad; Butler, Brittany; Laggner, Christian; Thayer, Desiree; Moharreri, Ehsan; Friedland, Greg; Truong, Ha; van den Bedem, Henry; Ng, Ho Leung; Stafford, Kate; Sarangapani, Krishna; Giesler, Kyle; Ngo, Lien; Mysinger, Michael; Ahmed, Mostafa; Anthis, Nicholas J.; Henriksen, Niel; Gniewek, Pawel; Eckert, Sam; de Oliveira, Saulo; Suterwala, Shabbir; PrasadPrasad, Srimukh Veccham Krishna; Shek, Stefani; Contreras, Stephanie; Hare, Stephanie; Palazzo, Teresa; O’Brien, Terrence E.; Van Grack, Tessa; Williams, Tiffany; Chern, Ting Rong; Kenyon, Victor; Lee, Andreia H.; Cann, Andrew B.; Bergman, Bastiaan; Anderson, Brandon M.; Virtanen, Anniina; Musta, Kirsikka; Silvennoinen, Olli; Haikarainen, Teemu (2024)
      article
      High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast ...

    • AI-driven wastewater management through comparative analysis of feature selection techniques and predictive models 

      Dikmen, Faruk; Demir, Ahmet; Özkaya, Bestami; Raza, Muhammad Owais; Rasheed, Jawad; Asuroglu, Tunc; Alsubai, Shtwai (2025)
      article
      The integration of artificial intelligence (AI) in wastewater treatment management offers a promising approach to optimizing effluent quality predictions and enhancing operational efficiency. This study evaluates the ...

    • Air pollution-induced proteomic alterations increase the risk of child respiratory infections 

      Brustad, Nicklas; Wang, Tingting; He, Shizhen; Pedersen, Casper Emil Tingskov; Gruzieva, Olena; Chen, Liang; Pershagen, Göran; Ali, Mina; Kyvsgaard, Julie Nyholm; Pedersen, Marie; Ketzel, Matthias; Hyöty, Heikki; Agardh, Daniel; Melén, Erik; Thorsen, Jonathan; Stokholm, Jakob; Bønnelykke, Klaus; Chawes, Bo (2025)
      article
      Early life air pollution exposure may play a role in development of respiratory infections, but underlying mechanisms are still not understood. We utilized data from two independent prospective birth cohorts to investigate ...

    • Alternative oxidase causes cell type- and tissue-specific responses in mutator mice 

      Ikonen, Lilli; Pirnes-Karhu, Sini; Pradhan, Swagat; Jacobs, Howard T.; Szibor, Marten; Suomalainen, Anu (2023)
      article
      Energetic insufficiency, excess production of reactive oxygen species (ROS), and aberrant signaling partially account for the diverse pathology of mitochondrial diseases. Whether interventions affecting ROS, a regulator ...

    • Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active 

      Giordano, Luca; Aneja, Manish K.; Sommer, Natascha; Alebrahimdehkordi, Nasim; Seraji, Alireza; Weissmann, Norbert; Rudolph, Carsten; Plank, Christian; Jacobs, Howard T.; Szibor, Marten (03 / 2021)
      article
      <p>Plants and other organisms, but not insects or vertebrates, express the auxiliary respiratory enzyme alternative oxidase (AOX) that bypasses mitochondrial respiratory complexes III and/or IV when impaired. Persistent ...

    • Analysis of spatial heterogeneity in normal epithelium and preneoplastic alterations in mouse prostate tumor models 

      Valkonen, Mira; Ruusuvuori, Pekka; Kartasalo, Kimmo; Nykter, Matti; Visakorpi, Tapio; Latonen, Leena (2017)
      article
      Cancer involves histological changes in tissue, which is of primary importance in pathological diagnosis and research. Automated histological analysis requires ability to computationally separate pathological alterations ...

    • Another message from Intergalactic Bacterial Command 

      Jacobs, Howy (2021)
      comment

    • AOX delays the onset of the lethal phenotype in a mouse model of Uqcrh (complex III) disease 

      Jacobs, Howard T.; Szibor, Marten; Rathkolb, Birgit; da Silva-Buttkus, Patricia; Aguilar-Pimentel, Juan Antonio; Amarie, Oana V.; Becker, Lore; Calzada-Wack, Julia; Dragano, Nathalia; Garrett, Lillian; Gerlini, Raffaele; Hölter, Sabine M.; Klein-Rodewald, Tanja; Kraiger, Markus; Leuchtenberger, Stefanie; Marschall, Susan; Östereicher, Manuela A.; Pfannes, Kristina; Sanz-Moreno, Adrián; Seisenberger, Claudia; Spielmann, Nadine; Stoeger, Claudia; Wurst, Wolfgang; Fuchs, Helmut; Hrabě de Angelis, Martin; Gailus-Durner, Valérie (10 / 2023)
      article
      <p>The alternative oxidase, AOX, provides a by-pass of the cytochrome segment of the mitochondrial respiratory chain when the chain is unavailable. AOX is absent from mammals, but AOX from Ciona intestinalis is benign ...

    • Artificial intelligence aided serum protein electrophoresis analysis of Finnish patient samples: Retrospective validation 

      Lahtiharju, Tapio; Paavolainen, Lassi; Suvisaari, Janne; Nokelainen, Pasi; Rotgers, Emmi; Anttonen, Mikko; Itkonen, Outi (01.02.2024)
      article
      Background and aims: Serum protein electrophoresis interpretation requires a substantial amount of manual work. In 2020, Chabrun et al. created a machine learning method called SPECTR for the task. We aimed to validate and ...

    • AS01-adjuvanted vaccine alters baseline correlates of T cell response to varicella zoster virus in older adults 

      Chan, Candice C.Y.; Ooi, Justin S.G.; Koh, Clara W.T.; Ong, Eugenia Z.; Tham, Christine Y.L.; Yee, Jia Xin; Chew, Valerie S.Y.; Cheung, Yin Bun; Ooi, Eng Eong; Low, Jenny G.; Chan, Kuan Rong (13.08.2025)
      article
      The recombinant zoster vaccine (RZV), which uses the AS01 adjuvant system, confers more than 90 % efficacy in older adults against herpes zoster. While most older adults have been exposed to chickenpox, it remains unclear ...

    • Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma 

      Flinkman, Ella; Vähätalo, Iida; Tuomisto, Leena E; Lehtimäki, Lauri; Nieminen, Pentti; Niemelä, Onni; Hämäläinen, Mari; Moilanen, Eeva; Kankaanranta, Hannu; Ilmarinen, Pinja (05.03.2022)
      article
      BACKGROUND: Asthma is a disease that can be separated into different phenotypes and endotypes based on the clinical characteristics and the molecular mechanisms of the condition, respectively.OBJECTIVE: To assess the ...

    • Association of ceramide risk scores with rheumatoid arthritis: a FINRISK population-based cohort study 

      Shoghli, Mohammadreza; Sinisalo, Juha; Lokki, A. Inkeri; Lääperi, Mitja; Lokki, Marja Liisa; Hilvo, Mika; Jylhä, Antti; Tuomilehto, Jaakko; Laaksonen, Reijo (12.03.2025)
      article
      Objectives This study aimed to explore the association between lipid-based Cardiovascular Event Risk Tests (CERT1 and CERT2), including ceramides (Cer) and phosphatidylcholine (PC) lipid species, and rheumatoid arthritis ...

    • Association of Serum Trimethylamine-N-Oxide Concentration from Childhood to Early Adulthood with Age and Sex 

      Almer, Gunter; Enko, Dietmar; Kartiosuo, Noora; Niinikoski, Harri; Lehtimäki, Terho; Munukka, Eveliina; Viikari, Jorma; Rönnemaa, Tapani; Rovio, Suvi P.; Mykkänen, Juha; Lagström, Hanna; Jula, Antti; Herrmann, Markus; Raitakari, Olli T.; Meinitzer, Andreas; Pahkala, Katja (09 / 2024)
      article
      Background: Primary prevention is the cornerstone of cardiometabolic health. In the randomized, controlled Special Turku Coronary Risk Factor Intervention Project (STRIP), dietary counseling intervention was given to ...

    • Associations of Prediabetes, Diabetes and Glucose-Related Markers With Cognition and Neuroimaging in a 2-Year Multidomain Lifestyle Randomised Controlled Trial 

      Lorenzo, Thais; Ngandu, Tiia; Lehtisalo, Jenni; Antikainen, Riitta; Gispert, Juan Domingo; Kemppainen, Nina; Laatikainen, Tiina; Lindström, Jaana; Rinne, Juha; Soininen, Hilkka; Strandberg, Timo; Torre, Rafael de la; Tuomilehto, Jaakko; Solomon, Alina; Kivipelto, Miia (07 / 2025)
      article
      Aims: Few longitudinal studies have explored Oral Glucose Tolerance Test markers (OGTT) and both cognitive and brain changes. We investigated OGTT and other glycaemia and insulin resistance markers, and cognitive and ...