Picornavirus infections and acute otitis media among young Finnish and Estonian children
Seppälä, Elina (2019)
2019
Master's Degree Programme in Health Sciences
Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences
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Hyväksymispäivämäärä
2019-02-20
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-201903061312
https://urn.fi/URN:NBN:fi:tuni-201903061312
Kuvaus
This thesis is based on the original article: Seppälä E., Oikarinen S., Lehtonen J., Neupane S., Sillanpää S., Laranne J., Knip M., Hyöty H., DIABIMMUNE Study Group. Picornavirus infections are associated with acute otitis media in a prospective Finnish-Estonian birth cohort study.
Tiivistelmä
Background. Human rhinoviruses (HRV), human enteroviruses (HEV) and human parechoviruses (HPeV) have been linked to acute otitis media (AOM). This association was evaluated in a prospective birth cohort setting.
Methods. 542 healthy infants were followed up from birth to the age of 3 years in the DIABIMMUNE study in Finland and Estonia. Stool samples were collected monthly and analyzed for HRV, HEV and HPeV. Nasal swab samples were collected at the age of 3, 6, 12, 18, 24 and 36 months, and screened for HRV and HEV. Parents recorded all AOM diagnoses in a diary. The association between virus detection in samples and AOM episodes was assessed by univariate and multivariate logistic regression.
Results. Altogether 1066 AOM episodes were recorded during the study period. 21%, 5% and 4% of the stool samples tested positive for HRV, HEV and HPeV, respectively. Of the nasal swab samples, 23% were positive for HRV and 2% for HEV. HRV and HPeV positivity of stool samples was associated with experiencing an AOM episode within two weeks before or after obtaining the stool sample (adjusted OR 1.42 [95% CI 1.00-2.01] for HRV and adjusted OR 2.00 [95% CI 1.12-3.55] for HPeV).
Conclusion. HRV, HEV and HPeV infections occur frequently in early childhood. These viruses may play an independent role in the development of AOM in children.
Methods. 542 healthy infants were followed up from birth to the age of 3 years in the DIABIMMUNE study in Finland and Estonia. Stool samples were collected monthly and analyzed for HRV, HEV and HPeV. Nasal swab samples were collected at the age of 3, 6, 12, 18, 24 and 36 months, and screened for HRV and HEV. Parents recorded all AOM diagnoses in a diary. The association between virus detection in samples and AOM episodes was assessed by univariate and multivariate logistic regression.
Results. Altogether 1066 AOM episodes were recorded during the study period. 21%, 5% and 4% of the stool samples tested positive for HRV, HEV and HPeV, respectively. Of the nasal swab samples, 23% were positive for HRV and 2% for HEV. HRV and HPeV positivity of stool samples was associated with experiencing an AOM episode within two weeks before or after obtaining the stool sample (adjusted OR 1.42 [95% CI 1.00-2.01] for HRV and adjusted OR 2.00 [95% CI 1.12-3.55] for HPeV).
Conclusion. HRV, HEV and HPeV infections occur frequently in early childhood. These viruses may play an independent role in the development of AOM in children.