TRIM24 and TDP-43 in prostate cancer
Flygare, Paulus (2018)
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Flygare, Paulus
2018
Lääketieteen lisensiaatin tutkinto-ohjelma - Licentiate's Degree Programme in Medicine
Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences
Hyväksymispäivämäärä
2018-12-13
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:uta-201901021020
https://urn.fi/URN:NBN:fi:uta-201901021020
Tiivistelmä
Prostate cancer has a high phenotypic homo- and genetic heterogeneity combined with highly variant clinical behavior. This creates a complex problem for the treatment and prediction of the prognoses of the patients. This study is aiming to contribute to the bigger research on the prostate cancer genomics and molecular biology in objective to advance the process of finding new clinical applications.
This study focuses on TRIM24 and TDP-43 and their associations and correlations to each other and other expression variables and prognostic factors: Ki67, primary PSA, Gleason score, T-score and progression free months.
The material used in the study are previously obtained clinical tumor samples processed with TMA technology.
In this study, we found significant difference in Ki67 expression between TRIM24-positive CRPC and PCa groups whereas difference wasn’t seen between the TRIM24-negative groups, indicating the possible association between these proteins in the progressed state of PCa. For TDP-43 we found that with higher staining scores in PCa with both nuclear and cytoplasmic groups may have association with better condition of the disease, whereas the opposite possible association was found in CRPC. Further studies are needed to confirm these findings.
This study focuses on TRIM24 and TDP-43 and their associations and correlations to each other and other expression variables and prognostic factors: Ki67, primary PSA, Gleason score, T-score and progression free months.
The material used in the study are previously obtained clinical tumor samples processed with TMA technology.
In this study, we found significant difference in Ki67 expression between TRIM24-positive CRPC and PCa groups whereas difference wasn’t seen between the TRIM24-negative groups, indicating the possible association between these proteins in the progressed state of PCa. For TDP-43 we found that with higher staining scores in PCa with both nuclear and cytoplasmic groups may have association with better condition of the disease, whereas the opposite possible association was found in CRPC. Further studies are needed to confirm these findings.