The identification and study of transcription factors and co-factors other than androgen receptor that could have important role in the regulation of gene expression in prostate tumor

Abstract

The overall aim of this study is to computationally identify and analyze the nature of transcription factors other than androgen receptor (AR) that play an important role in the regulation of gene expression and the subsequent progression of the castrate-resistant prostate cancer (CRPC). Anti-androgen therapy would relapse in about 20% of the treated patients leading to the development of drug resistance in CRPC. This leads to the search for other transcription factors and cofactors as suitable drug targets other than AR that have a role in proliferation of the prostate cancer cells in CRPC. The study of these transcription factors could highlight a possible role in determining an alternative treatment approach in contrast to current methods that focus primarily on AR-dependent pathways. These transcription factors also have important role in the common prostate cancer and is not displayed much due to the more active AR signaling.