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Conservative treatment, plate fixation, or prosthesis for proximal humeral fracture. A prospective randomized study

Launonen, Antti P; Lepola, Vesa; Flinkkilä, Tapio; Strandberg, Niko; Ojanperä, Johanna; Rissanen, Pekka; Malmivaara, Antti; Mattila, Ville M; Elo, Petra; Viljakka, Timo; Laitinen, Minna (2012)

 
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conservative_treatment_plate_fixation_2012.pdf (462.5Kt)
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Launonen, Antti P
Lepola, Vesa
Flinkkilä, Tapio
Strandberg, Niko
Ojanperä, Johanna
Rissanen, Pekka
Malmivaara, Antti
Mattila, Ville M
Elo, Petra
Viljakka, Timo
Laitinen, Minna
2012

BMC Musculoskeletal Disorders 13
167
This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited.
doi:10.1186/1471-2474-13-167
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Julkaisun pysyvä osoite on
http://urn.fi/URN:NBN:fi:uta-201301111008

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BioMed Central open access
Tiivistelmä
Background

Proximal humerus fracture is the third most common fracture type after hip and distal radius fracture in elderly patients. A comprehensive study by Palvanen et al. demonstrated an increase in the annual fracture rate of 13.7% per year over the past 33 years. Should this trend continue, the fracture rate would triple over the next three decades. The increasing incidence of low-energy fractures raises questions about the optimal treatment in terms of functional outcome, pain, and rehabilitation time, as well as the economical impact. Despite the high incidence and costs of proximal humerus fractures, there is currently no valid scientific evidence for the best treatment method. Several publications, including a Cochrane review outline the need for high-quality, well-designed randomized controlled trials.
Methods/Design

The study is a prospective, randomized, national multi-center trial. The hypothesis of the trial is that surgical treatment of displaced proximal humerus fractures achieves better functional outcome, pain relief, and patient satisfaction compared to conservative treatment. The trial is designed to compare conservative and surgical treatment of proximal humerus fractures in patients 60 years and older. The trial includes two strata. Stratum I compares surgical treatment with locking plates to conservative treatment for two-part fractures. Stratum II compares multi-fragmented fractures, including three- and four-part fractures. The aim of Stratum II is to compare conservative treatment, surgical treatment with the Philos locking plate, and hemiarthroplasty with an Epoca prosthesis. The primary outcome measure will be the Disabilities of the Arm, Shoulder and Hand (DASH) score and the secondary outcome measures will be the EuroQol-5D (EQ-5D) value, OSS, Constant-Murley Score, VAS, and 15D.

Recruiting time will be 3 years. The results will be analyzed after the 2-year follow-up period.
Discussion

This publication presents a prospective, randomized, national multi-center trial. It gives details of patient flow, randomization, aftercare and also ways of analysis of the material and ways to present and publish the results.
Trial registration

ClinicalTrials.gov identifier: NCT01246167
Keywords:
Proximal; Humerus; Fracture; Conservative; Operative; Locking plate; Prosthesis; Philos; Epoca; RCT
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