Opium use and risk of lung cancer : A multicenter case-control study in Iran
Rashidian, Hamideh; Hadji, Maryam; Gholipour, Mahin; Naghibzadeh-Tahami, Ahmad; Marzban, Maryam; Mohebbi, Elham; Safari-Faramani, Roya; Bakhshi, Mahdieh; Sadat Seyyedsalehi, Monireh; Hosseini, Bayan; Alizadeh-Navaei, Reza; Emami, Habib; Haghdoost, Ali Akbar; Rezaianzadeh, Abbas; Moradi, Abdolvahab; Ansari-Moghaddam, Alireza; Nejatizadeh, Azim; ShahidSales, Soodabeh; Rezvani, Alireza; Larizadeh, Mohammad Hasan; Najafi, Farid; Poustchi, Hossein; Mohagheghi, Mohammad Ali; Brennan, Paul; Weiderpass, Elisabete; Schüz, Joachim; Pukkala, Eero; Freedman, Neal D.; Boffetta, Paolo; Malekzadeh, Reza; Etemadi, Arash; Rahimi-Movaghar, Afarin; Kamangar, Farin; Zendehdel, Kazem (2023-01-15)
Rashidian, Hamideh
Hadji, Maryam
Gholipour, Mahin
Naghibzadeh-Tahami, Ahmad
Marzban, Maryam
Mohebbi, Elham
Safari-Faramani, Roya
Bakhshi, Mahdieh
Sadat Seyyedsalehi, Monireh
Hosseini, Bayan
Alizadeh-Navaei, Reza
Emami, Habib
Haghdoost, Ali Akbar
Rezaianzadeh, Abbas
Moradi, Abdolvahab
Ansari-Moghaddam, Alireza
Nejatizadeh, Azim
ShahidSales, Soodabeh
Rezvani, Alireza
Larizadeh, Mohammad Hasan
Najafi, Farid
Poustchi, Hossein
Mohagheghi, Mohammad Ali
Brennan, Paul
Weiderpass, Elisabete
Schüz, Joachim
Pukkala, Eero
Freedman, Neal D.
Boffetta, Paolo
Malekzadeh, Reza
Etemadi, Arash
Rahimi-Movaghar, Afarin
Kamangar, Farin
Zendehdel, Kazem
15.01.2023
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-2023113010361
https://urn.fi/URN:NBN:fi:tuni-2023113010361
Kuvaus
Peer reviewed
Tiivistelmä
Opium use was recently classified as a human carcinogen for lung cancer by the International Agency for Research on Cancer. We conducted a large, multicenter case-control study evaluating the association between opium use and the risk of lung cancer. We recruited 627 cases and 3477 controls from May 2017 to July 2020. We used unconditional logistic regression analyses to estimate the odds ratios (OR) and 95% confidence intervals (CI) and measured the association between opium use and the risk of lung cancer. The ORs were adjusted for the residential place, age, gender, socioeconomic status, cigarettes, and water pipe smoking. We found a 3.6-fold risk of lung cancer for regular opium users compared to never users (95% CI: 2.9, 4.6). There was a strong dose-response association between a cumulative count of opium use and lung cancer risk. The OR for regular opium use was higher for small cell carcinoma than in other histology (8.3, 95% CI: 4.8, 14.4). The OR of developing lung cancer among opium users was higher in females (7.4, 95% CI: 3.8, 14.5) than in males (3.3, 95% CI: 2.6, 4.2). The OR for users of both opium and tobacco was 13.4 (95% CI: 10.2, 17.7) compared to nonusers of anything. The risk of developing lung cancer is higher in regular opium users, and these results strengthen the conclusions on the carcinogenicity of opium. The association is stronger for small cell carcinoma cases than in other histology.
Kokoelmat
- TUNICRIS-julkaisut [18885]