Hypertensive pregnancy complications and maternal characteristics as predictors of cardiovascular health within ten years after delivery
The FINNPEC Study Group; Kivelä, Anni; Heinonen, Seppo; Kivinen, Katja; Kere, Juha; Kajantie, Eero; Jääskeläinen, Tiina; Laivuori, Hannele (2023-12)
The FINNPEC Study Group
Kivelä, Anni
Heinonen, Seppo
Kivinen, Katja
Kere, Juha
Kajantie, Eero
Jääskeläinen, Tiina
Laivuori, Hannele
12 / 2023
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202309268454
https://urn.fi/URN:NBN:fi:tuni-202309268454
Kuvaus
Peer reviewed
Tiivistelmä
Objective: To identify the combination of maternal characteristics in women with hypertensive disorders of pregnancy (HDP) associated with hypertensive and other cardiovascular diseases (CVDs) within ten years following delivery. The aim is to understand who should receive the most intensive primary cardiovascular disease prevention. Study design: A prospective cohort study. Main outcome: The population was the FINNPEC cohort (2008–2011), including women with (n = 1837) and without (n = 847) HDP. The main exposures were maternal hypertensive pregnancy complications linked with maternal pregnancy data from hospital records. The outcomes were hypertensive diseases and other CVDs (International Classification of Diseases, Tenth Revision). Results: Women with de novo pre-eclampsia (PE) had an elevated risk for hypertensive diseases within ten years following delivery. The risk of CVD was increased in women with superimposed PE and chronic hypertension (CHT) only. Women with de novo PE and hypertensive diseases were more often primiparous (41.4% vs. 23.0%, p = 0.020), had gestational diabetes (GDM) (31.0% vs. 11.7%, p = 0.002), and higher pre-pregnancy body mass index (BMI) (28.7 ± 5.8 vs. 24.6 ± 4.8 kg/m2, p = 0.001), compared with women who remained normotensive. Women with superimposed PE with CVD had more likely early-onset PE, preterm delivery and were older than women without later CVD. Conclusions: Healthcare professionals should target early prevention of CVDs in women with chronic hypertension during pregnancy; of those who developed superimposed PE prior to 34th weeks of gestation and who delivered preterm. Women with de novo PE who are overweight/obese, primiparous, and with concurrent GDM need regular blood pressure monitoring.
Kokoelmat
- TUNICRIS-julkaisut [19239]