Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, Stavroula; Graham, Sarah E; Wang, Yuxuan; Surakka, Ida; Ramdas, Shweta; Zhu, Xiang; Clarke, Shoa L; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W; Locke, Adam E; Marouli, Eirini; Zajac, Greg J M; Wu, Kuan-Han H; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han, Sohee; Akiyama, Masato; Sakaue, Saori; Terao, Chikashi; Kanai, Masahiro; Zhou, Wei; Brumpton, Ben M; Rasheed, Humaira; Havulinna, Aki S; Veturi, Yogasudha; Pacheco, Jennifer Allen; Rosenthal, Elisabeth A; Lingren, Todd; Feng, QiPing; Kullo, Iftikhar J; Narita, Akira; Takayama, Jun; Martin, Hilary C; Hunt, Karen A; Trivedi, Bhavi; Haessler, Jeffrey; Giulianini, Franco; Bradford, Yuki; Miller, Jason E; Campbell, Archie; Lin, Kuang; Millwood, Iona Y; Rasheed, Asif; Hindy, George; Faul, Jessica D; Zhao, Wei; Weir, David R; Turman, Constance; Huang, Hongyan; Graff, Mariaelisa; Choudhury, Ananyo; Sengupta, Dhriti; Mahajan, Anubha; Brown, Michael R; Zhang, Weihua; Yu, Ketian; Schmidt, Ellen M; Pandit, Anita; Gustafsson, Stefan; Yin, Xianyong; Luan, Jian'an; Zhao, Jing-Hua; Matsuda, Fumihiko; Jang, Hye-Mi; Yoon, Kyungheon; Medina-Gomez, Carolina; Pitsillides, Achilleas; Hottenga, Jouke Jan; Wood, Andrew R; Ji, Yingji; Gao, Zishan; Haworth, Simon; Yousri, Noha A; Mitchell, Ruth E; Chai, Jin Fang; Aadahl, Mette; Bjerregaard, Anne A; Yao, Jie; Manichaikul, Ani; Hwu, Chii-Min; Hung, Yi-Jen; Warren, Helen R; Ramirez, Julia; Bork-Jensen, Jette; Kårhus, Line L; Goel, Anuj; Sabater-Lleal, Maria; Noordam, Raymond; Mauro, Pala; Matteo, Floris; McDaid, Aaron F; Marques-Vidal, Pedro; Wielscher, Matthias; Trompet, Stella; Sattar, Naveed; Møllehave, Line T; Munz, Matthias; Zeng, Lingyao; Huang, Jianfeng; Yang, Bin; Poveda, Alaitz; Kurbasic, Azra; Lamina, Claudia; Forer, Lukas; Scholz, Markus; Galesloot, Tessel E; Bradfield, Jonathan P; Ruotsalainen, Sanni E; Daw, EWarwick; Zmuda, Joseph M; Mitchell, Jonathan S; Fuchsberger, Christian; Christensen, Henry; Brody, Jennifer A; Vazquez-Moreno, Miguel; Feitosa, Mary F; Wojczynski, Mary K; Wang, Zhe; Preuss, Michael H; Mangino, Massimo; Christofidou, Paraskevi; Verweij, Niek; Benjamins, Jan W; Engmann, Jorgen; Tsao, Noah L; Verma, Anurag; Slieker, Roderick C; Lo, Ken Sin; Zilhao, Nuno R; Le, Phuong; Kleber, Marcus E; Delgado, Graciela E; Huo, Shaofeng; Ikeda, Daisuke D; Iha, Hiroyuki; Yang, Jian; Liu, Jun; Demirkan, Ayşe; Leonard, Hampton L; Marten, Jonathan; Frank, Mirjam; Schmidt, Börge; Smyth, Laura J; Cañadas-Garre, Marisa; Wang, Chaolong; Nakatochi, Masahiro; Wong, Andrew; Hutri-Kähönen, Nina; Sim, Xueling; Xia, Rui; Huerta-Chagoya, Alicia; Fernandez-Lopez, Juan Carlos; Lyssenko, Valeriya; Nongmaithem, Suraj S; Bayyana, Swati; Stringham, Heather M; Irvin, Marguerite R; Oldmeadow, Christopher; Kim, Han-Na; Ryu, Seungho; Timmers, Paul R H J; Arbeeva, Liubov; Dorajoo, Rajkumar; Lange, Leslie A; Prasad, Gauri; Lorés-Motta, Laura; Pauper, Marc; Long, Jirong; Li, Xiaohui; Theusch, Elizabeth; Takeuchi, Fumihiko; Spracklen, Cassandra N; Loukola, Anu; Bollepalli, Sailalitha; Warner, Sophie C; Wang, Ya Xing; Wei, Wen B; Nutile, Teresa; Ruggiero, Daniela; Sung, Yun Ju; Chen, Shufeng; Liu, Fangchao; Yang, Jingyun; Kentistou, Katherine A; Banas, Bernhard; Nardone, Giuseppe Giovanni; Meidtner, Karina; Bielak, Lawrence F; Smith, Jennifer A; Hebbar, Prashantha; Farmaki, Aliki-Eleni; Hofer, Edith; Lin, Maoxuan; Concas, Maria Pina; Vaccargiu, Simona; van der Most, Peter J; Pitkänen, Niina; Cade, Brian E; van der Laan, Sander W; Chitrala, Kumaraswamy Naidu; Weiss, Stefan; Bentley, Amy R; Doumatey, Ayo P; Adeyemo, Adebowale A; Lee, Jong Young; Petersen, Eva R B; Nielsen, Aneta A; Choi, Hyeok Sun; Nethander, Maria; Freitag-Wolf, Sandra; Southam, Lorraine; Rayner, Nigel W; Wang, Carol A; Lin, Shih-Yi; Wang, Jun-Sing; Couture, Christian; Lyytikäinen, Leo-Pekka; Nikus, Kjell; Cuellar-Partida, Gabriel; Vestergaard, Henrik; Hidalgo, Bertha; Giannakopoulou, Olga; Cai, Qiuyin; Obura, Morgan O; van Setten, Jessica; Li, Xiaoyin; Liang, Jingjing; Tang, Hua; Terzikhan, Natalie; Shin, Jae Hun; Jackson, Rebecca D; Reiner, Alexander P; Martin, Lisa Warsinger; Chen, Zhengming; Li, Liming; Kawaguchi, Takahisa; Thiery, Joachim; Bis, Joshua C; Launer, Lenore J; Li, Huaixing; Nalls, Mike A; Raitakari, Olli T; Ichihara, Sahoko; Wild, Sarah H; Nelson, Christopher P; Campbell, Harry; Jäger, Susanne; Nabika, Toru; Al-Mulla, Fahd; Niinikoski, Harri; Braund, Peter S; Kolcic, Ivana; Kovacs, Peter; Giardoglou, Tota; Katsuya, Tomohiro; de Kleijn, Dominique; de Borst, Gert J; Kim, Eung Kweon; Adams, Hieab H H; Ikram, M Arfan; Zhu, Xiaofeng; Asselbergs, Folkert W; Kraaijeveld, Adriaan O; Beulens, Joline W J; Shu, Xiao-Ou; Rallidis, Loukianos S; Pedersen, Oluf; Hansen, Torben; Mitchell, Paul; Hewitt, Alex W; Kähönen, Mika; Pérusse, Louis; Bouchard, Claude; Tönjes, Anke; Chen, Yii-Der Ida; Pennell, Craig E; Mori, Trevor A; Lieb, Wolfgang; Franke, Andre; Ohlsson, Claes; Mellström, Dan; Cho, Yoon Shin; Lee, Hyejin; Yuan, Jian-Min; Koh, Woon-Puay; Rhee, Sang Youl; Woo, Jeong-Taek; Heid, Iris M; Stark, Klaus J; Zimmermann, Martina E; Völzke, Henry; Homuth, Georg; Evans, Michele K; Zonderman, Alan B; Polasek, Ozren; Pasterkamp, Gerard; Hoefer, Imo E; Redline, Susan; Pahkala, Katja; Oldehinkel, Albertine J; Snieder, Harold; Biino, Ginevra; Schmidt, Reinhold; Schmidt, Helena; Bandinelli, Stefania; Dedoussis, George; Thanaraj, Thangavel Alphonse; Kardia, Sharon L R; Peyser, Patricia A; Kato, Norihiro; Schulze, Matthias B; Girotto, Giorgia; Böger, Carsten A; Jung, Bettina; Joshi, Peter K; Bennett, David A; De Jager, Philip L; Lu, Xiangfeng; Mamakou, Vasiliki; Brown, Morris; Caulfield, Mark J; Munroe, Patricia B; Guo, Xiuqing; Ciullo, Marina; Jonas, Jost B; Samani, Nilesh J; Kaprio, Jaakko; Pajukanta, Päivi; Tusié-Luna, Teresa; Aguilar-Salinas, Carlos A; Adair, Linda S; Bechayda, Sonny Augustin; de Silva, H Janaka; Wickremasinghe, Ananda R; Krauss, Ronald M; Wu, Jer-Yuarn; Zheng, Wei; Hollander, Anneke Iden; Bharadwaj, Dwaipayan; Correa, Adolfo; Wilson, James G; Lind, Lars; Heng, Chew-Kiat; Nelson, Amanda E; Golightly, Yvonne M; Wilson, James F; Penninx, Brenda; Kim, Hyung-Lae; Attia, John; Scott, Rodney J; Rao, D C; Arnett, Donna K; Hunt, Steven C; Walker, Mark; Koistinen, Heikki A; Chandak, Giriraj R; Mercader, Josep M; Costanzo, Maria C; Jang, Dongkeun; Burtt, Noël P; Villalpando, Clicerio Gonzalez; Orozco, Lorena; Fornage, Myriam; Tai, EShyong; van Dam, Rob M; Lehtimäki, Terho; Chaturvedi, Nish; Yokota, Mitsuhiro; Liu, Jianjun; Reilly, Dermot F; McKnight, Amy Jayne; Kee, Frank; Jöckel, Karl-Heinz; McCarthy, Mark I; Palmer, Colin N A; Vitart, Veronique; Hayward, Caroline; Simonsick, Eleanor; van Duijn, Cornelia M; Jin, Zi-Bing; Qu, Jia; Hishigaki, Haretsugu; Lin, Xu; März, Winfried; Gudnason, Vilmundur; Tardif, Jean-Claude; Lettre, Guillaume; Hart, Leen M 't; Elders, Petra J M; Damrauer, Scott M; Kumari, Meena; Kivimaki, Mika; van der Harst, Pim; Spector, Tim D; Loos, Ruth J F; Province, Michael A; Parra, Esteban J; Cruz, Miguel; Psaty, Bruce M; Brandslund, Ivan; Pramstaller, Peter P; Rotimi, Charles N; Christensen, Kaare; Ripatti, Samuli; Widén, Elisabeth; Hakonarson, Hakon; Grant, Struan F A; Kiemeney, Lambertus A L M; de Graaf, Jacqueline; Loeffler, Markus; Kronenberg, Florian; Gu, Dongfeng; Erdmann, Jeanette; Schunkert, Heribert; Franks, Paul W; Linneberg, Allan; Jukema, J Wouter; Khera, Amit V; Männikkö, Minna; Jarvelin, Marjo-Riitta; Kutalik, Zoltan; Francesco, Cucca; Mook-Kanamori, Dennis O; van Dijk, Ko Willems; Watkins, Hugh; Strachan, David P; Grarup, Niels; Sever, Peter; Poulter, Neil; Chuang, Lee-Ming; Rotter, Jerome I; Dantoft, Thomas M; Karpe, Fredrik; Neville, Matt J; Timpson, Nicholas J; Cheng, Ching-Yu; Wong, Tien-Yin; Khor, Chiea Chuen; Li, Hengtong; Sabanayagam, Charumathi; Peters, Annette; Gieger, Christian; Hattersley, Andrew T; Pedersen, Nancy L; Magnusson, Patrik K E; Boomsma, Dorret I; Willemsen, Allegonda H M; Cupples, LAdrienne; van Meurs, Joyce B J; Ghanbari, Mohsen; Gordon-Larsen, Penny; Huang, Wei; Kim, Young Jin; Tabara, Yasuharu; Wareham, Nicholas J; Langenberg, Claudia; Zeggini, Eleftheria; Kuusisto, Johanna; Laakso, Markku; Ingelsson, Erik; Abecasis, Goncalo; Chambers, John C; Kooner, Jaspal S; de Vries, Paul S; Morrison, Alanna C; Hazelhurst, Scott; Ramsay, Michèle; North, Kari E; Daviglus, Martha; Kraft, Peter; Martin, Nicholas G; Whitfield, John B; Abbas, Shahid; Saleheen, Danish; Walters, Robin G; Holmes, Michael V; Black, Corri; Smith, Blair H; Baras, Aris; Justice, Anne E; Buring, Julie E; Ridker, Paul M; Chasman, Daniel I; Kooperberg, Charles; Tamiya, Gen; Yamamoto, Masayuki; van Heel, David A; Trembath, Richard C; Wei, Wei-Qi; Jarvik, Gail P; Namjou, Bahram; Hayes, M Geoffrey; Ritchie, Marylyn D; Jousilahti, Pekka; Salomaa, Veikko; Hveem, Kristian; Åsvold, Bjørn Olav; Kubo, Michiaki; Kamatani, Yoichiro; Okada, Yukinori; Murakami, Yoshinori; Kim, Bong-Jo; Thorsteinsdottir, Unnur; Stefansson, Kari; Zhang, Jifeng; Chen, YEugene; Ho, Yuk-Lam; Lynch, Julie A; Rader, Daniel J; Tsao, Philip S; Chang, Kyong-Mi; Cho, Kelly; O'Donnell, Christopher J; Gaziano, John M; Wilson, Peter W F; Frayling, Timothy M; Hirschhorn, Joel N; Kathiresan, Sekar; Mohlke, Karen L; Sun, Yan V; Morris, Andrew P; Boehnke, Michael; Brown, Christopher D; Natarajan, Pradeep; Deloukas, Panos; Willer, Cristen J; Assimes, Themistocles L; Peloso, Gina M (2022-12-27)
Kanoni, Stavroula
Graham, Sarah E
Wang, Yuxuan
Surakka, Ida
Ramdas, Shweta
Zhu, Xiang
Clarke, Shoa L
Bhatti, Konain Fatima
Vedantam, Sailaja
Winkler, Thomas W
Locke, Adam E
Marouli, Eirini
Zajac, Greg J M
Wu, Kuan-Han H
Ntalla, Ioanna
Hui, Qin
Klarin, Derek
Hilliard, Austin T
Wang, Zeyuan
Xue, Chao
Thorleifsson, Gudmar
Helgadottir, Anna
Gudbjartsson, Daniel F
Holm, Hilma
Olafsson, Isleifur
Hwang, Mi Yeong
Han, Sohee
Akiyama, Masato
Sakaue, Saori
Terao, Chikashi
Kanai, Masahiro
Zhou, Wei
Brumpton, Ben M
Rasheed, Humaira
Havulinna, Aki S
Veturi, Yogasudha
Pacheco, Jennifer Allen
Rosenthal, Elisabeth A
Lingren, Todd
Feng, QiPing
Kullo, Iftikhar J
Narita, Akira
Takayama, Jun
Martin, Hilary C
Hunt, Karen A
Trivedi, Bhavi
Haessler, Jeffrey
Giulianini, Franco
Bradford, Yuki
Miller, Jason E
Campbell, Archie
Lin, Kuang
Millwood, Iona Y
Rasheed, Asif
Hindy, George
Faul, Jessica D
Zhao, Wei
Weir, David R
Turman, Constance
Huang, Hongyan
Graff, Mariaelisa
Choudhury, Ananyo
Sengupta, Dhriti
Mahajan, Anubha
Brown, Michael R
Zhang, Weihua
Yu, Ketian
Schmidt, Ellen M
Pandit, Anita
Gustafsson, Stefan
Yin, Xianyong
Luan, Jian'an
Zhao, Jing-Hua
Matsuda, Fumihiko
Jang, Hye-Mi
Yoon, Kyungheon
Medina-Gomez, Carolina
Pitsillides, Achilleas
Hottenga, Jouke Jan
Wood, Andrew R
Ji, Yingji
Gao, Zishan
Haworth, Simon
Yousri, Noha A
Mitchell, Ruth E
Chai, Jin Fang
Aadahl, Mette
Bjerregaard, Anne A
Yao, Jie
Manichaikul, Ani
Hwu, Chii-Min
Hung, Yi-Jen
Warren, Helen R
Ramirez, Julia
Bork-Jensen, Jette
Kårhus, Line L
Goel, Anuj
Sabater-Lleal, Maria
Noordam, Raymond
Mauro, Pala
Matteo, Floris
McDaid, Aaron F
Marques-Vidal, Pedro
Wielscher, Matthias
Trompet, Stella
Sattar, Naveed
Møllehave, Line T
Munz, Matthias
Zeng, Lingyao
Huang, Jianfeng
Yang, Bin
Poveda, Alaitz
Kurbasic, Azra
Lamina, Claudia
Forer, Lukas
Scholz, Markus
Galesloot, Tessel E
Bradfield, Jonathan P
Ruotsalainen, Sanni E
Daw, EWarwick
Zmuda, Joseph M
Mitchell, Jonathan S
Fuchsberger, Christian
Christensen, Henry
Brody, Jennifer A
Vazquez-Moreno, Miguel
Feitosa, Mary F
Wojczynski, Mary K
Wang, Zhe
Preuss, Michael H
Mangino, Massimo
Christofidou, Paraskevi
Verweij, Niek
Benjamins, Jan W
Engmann, Jorgen
Tsao, Noah L
Verma, Anurag
Slieker, Roderick C
Lo, Ken Sin
Zilhao, Nuno R
Le, Phuong
Kleber, Marcus E
Delgado, Graciela E
Huo, Shaofeng
Ikeda, Daisuke D
Iha, Hiroyuki
Yang, Jian
Liu, Jun
Demirkan, Ayşe
Leonard, Hampton L
Marten, Jonathan
Frank, Mirjam
Schmidt, Börge
Smyth, Laura J
Cañadas-Garre, Marisa
Wang, Chaolong
Nakatochi, Masahiro
Wong, Andrew
Hutri-Kähönen, Nina
Sim, Xueling
Xia, Rui
Huerta-Chagoya, Alicia
Fernandez-Lopez, Juan Carlos
Lyssenko, Valeriya
Nongmaithem, Suraj S
Bayyana, Swati
Stringham, Heather M
Irvin, Marguerite R
Oldmeadow, Christopher
Kim, Han-Na
Ryu, Seungho
Timmers, Paul R H J
Arbeeva, Liubov
Dorajoo, Rajkumar
Lange, Leslie A
Prasad, Gauri
Lorés-Motta, Laura
Pauper, Marc
Long, Jirong
Li, Xiaohui
Theusch, Elizabeth
Takeuchi, Fumihiko
Spracklen, Cassandra N
Loukola, Anu
Bollepalli, Sailalitha
Warner, Sophie C
Wang, Ya Xing
Wei, Wen B
Nutile, Teresa
Ruggiero, Daniela
Sung, Yun Ju
Chen, Shufeng
Liu, Fangchao
Yang, Jingyun
Kentistou, Katherine A
Banas, Bernhard
Nardone, Giuseppe Giovanni
Meidtner, Karina
Bielak, Lawrence F
Smith, Jennifer A
Hebbar, Prashantha
Farmaki, Aliki-Eleni
Hofer, Edith
Lin, Maoxuan
Concas, Maria Pina
Vaccargiu, Simona
van der Most, Peter J
Pitkänen, Niina
Cade, Brian E
van der Laan, Sander W
Chitrala, Kumaraswamy Naidu
Weiss, Stefan
Bentley, Amy R
Doumatey, Ayo P
Adeyemo, Adebowale A
Lee, Jong Young
Petersen, Eva R B
Nielsen, Aneta A
Choi, Hyeok Sun
Nethander, Maria
Freitag-Wolf, Sandra
Southam, Lorraine
Rayner, Nigel W
Wang, Carol A
Lin, Shih-Yi
Wang, Jun-Sing
Couture, Christian
Lyytikäinen, Leo-Pekka
Nikus, Kjell
Cuellar-Partida, Gabriel
Vestergaard, Henrik
Hidalgo, Bertha
Giannakopoulou, Olga
Cai, Qiuyin
Obura, Morgan O
van Setten, Jessica
Li, Xiaoyin
Liang, Jingjing
Tang, Hua
Terzikhan, Natalie
Shin, Jae Hun
Jackson, Rebecca D
Reiner, Alexander P
Martin, Lisa Warsinger
Chen, Zhengming
Li, Liming
Kawaguchi, Takahisa
Thiery, Joachim
Bis, Joshua C
Launer, Lenore J
Li, Huaixing
Nalls, Mike A
Raitakari, Olli T
Ichihara, Sahoko
Wild, Sarah H
Nelson, Christopher P
Campbell, Harry
Jäger, Susanne
Nabika, Toru
Al-Mulla, Fahd
Niinikoski, Harri
Braund, Peter S
Kolcic, Ivana
Kovacs, Peter
Giardoglou, Tota
Katsuya, Tomohiro
de Kleijn, Dominique
de Borst, Gert J
Kim, Eung Kweon
Adams, Hieab H H
Ikram, M Arfan
Zhu, Xiaofeng
Asselbergs, Folkert W
Kraaijeveld, Adriaan O
Beulens, Joline W J
Shu, Xiao-Ou
Rallidis, Loukianos S
Pedersen, Oluf
Hansen, Torben
Mitchell, Paul
Hewitt, Alex W
Kähönen, Mika
Pérusse, Louis
Bouchard, Claude
Tönjes, Anke
Chen, Yii-Der Ida
Pennell, Craig E
Mori, Trevor A
Lieb, Wolfgang
Franke, Andre
Ohlsson, Claes
Mellström, Dan
Cho, Yoon Shin
Lee, Hyejin
Yuan, Jian-Min
Koh, Woon-Puay
Rhee, Sang Youl
Woo, Jeong-Taek
Heid, Iris M
Stark, Klaus J
Zimmermann, Martina E
Völzke, Henry
Homuth, Georg
Evans, Michele K
Zonderman, Alan B
Polasek, Ozren
Pasterkamp, Gerard
Hoefer, Imo E
Redline, Susan
Pahkala, Katja
Oldehinkel, Albertine J
Snieder, Harold
Biino, Ginevra
Schmidt, Reinhold
Schmidt, Helena
Bandinelli, Stefania
Dedoussis, George
Thanaraj, Thangavel Alphonse
Kardia, Sharon L R
Peyser, Patricia A
Kato, Norihiro
Schulze, Matthias B
Girotto, Giorgia
Böger, Carsten A
Jung, Bettina
Joshi, Peter K
Bennett, David A
De Jager, Philip L
Lu, Xiangfeng
Mamakou, Vasiliki
Brown, Morris
Caulfield, Mark J
Munroe, Patricia B
Guo, Xiuqing
Ciullo, Marina
Jonas, Jost B
Samani, Nilesh J
Kaprio, Jaakko
Pajukanta, Päivi
Tusié-Luna, Teresa
Aguilar-Salinas, Carlos A
Adair, Linda S
Bechayda, Sonny Augustin
de Silva, H Janaka
Wickremasinghe, Ananda R
Krauss, Ronald M
Wu, Jer-Yuarn
Zheng, Wei
Hollander, Anneke Iden
Bharadwaj, Dwaipayan
Correa, Adolfo
Wilson, James G
Lind, Lars
Heng, Chew-Kiat
Nelson, Amanda E
Golightly, Yvonne M
Wilson, James F
Penninx, Brenda
Kim, Hyung-Lae
Attia, John
Scott, Rodney J
Rao, D C
Arnett, Donna K
Hunt, Steven C
Walker, Mark
Koistinen, Heikki A
Chandak, Giriraj R
Mercader, Josep M
Costanzo, Maria C
Jang, Dongkeun
Burtt, Noël P
Villalpando, Clicerio Gonzalez
Orozco, Lorena
Fornage, Myriam
Tai, EShyong
van Dam, Rob M
Lehtimäki, Terho
Chaturvedi, Nish
Yokota, Mitsuhiro
Liu, Jianjun
Reilly, Dermot F
McKnight, Amy Jayne
Kee, Frank
Jöckel, Karl-Heinz
McCarthy, Mark I
Palmer, Colin N A
Vitart, Veronique
Hayward, Caroline
Simonsick, Eleanor
van Duijn, Cornelia M
Jin, Zi-Bing
Qu, Jia
Hishigaki, Haretsugu
Lin, Xu
März, Winfried
Gudnason, Vilmundur
Tardif, Jean-Claude
Lettre, Guillaume
Hart, Leen M 't
Elders, Petra J M
Damrauer, Scott M
Kumari, Meena
Kivimaki, Mika
van der Harst, Pim
Spector, Tim D
Loos, Ruth J F
Province, Michael A
Parra, Esteban J
Cruz, Miguel
Psaty, Bruce M
Brandslund, Ivan
Pramstaller, Peter P
Rotimi, Charles N
Christensen, Kaare
Ripatti, Samuli
Widén, Elisabeth
Hakonarson, Hakon
Grant, Struan F A
Kiemeney, Lambertus A L M
de Graaf, Jacqueline
Loeffler, Markus
Kronenberg, Florian
Gu, Dongfeng
Erdmann, Jeanette
Schunkert, Heribert
Franks, Paul W
Linneberg, Allan
Jukema, J Wouter
Khera, Amit V
Männikkö, Minna
Jarvelin, Marjo-Riitta
Kutalik, Zoltan
Francesco, Cucca
Mook-Kanamori, Dennis O
van Dijk, Ko Willems
Watkins, Hugh
Strachan, David P
Grarup, Niels
Sever, Peter
Poulter, Neil
Chuang, Lee-Ming
Rotter, Jerome I
Dantoft, Thomas M
Karpe, Fredrik
Neville, Matt J
Timpson, Nicholas J
Cheng, Ching-Yu
Wong, Tien-Yin
Khor, Chiea Chuen
Li, Hengtong
Sabanayagam, Charumathi
Peters, Annette
Gieger, Christian
Hattersley, Andrew T
Pedersen, Nancy L
Magnusson, Patrik K E
Boomsma, Dorret I
Willemsen, Allegonda H M
Cupples, LAdrienne
van Meurs, Joyce B J
Ghanbari, Mohsen
Gordon-Larsen, Penny
Huang, Wei
Kim, Young Jin
Tabara, Yasuharu
Wareham, Nicholas J
Langenberg, Claudia
Zeggini, Eleftheria
Kuusisto, Johanna
Laakso, Markku
Ingelsson, Erik
Abecasis, Goncalo
Chambers, John C
Kooner, Jaspal S
de Vries, Paul S
Morrison, Alanna C
Hazelhurst, Scott
Ramsay, Michèle
North, Kari E
Daviglus, Martha
Kraft, Peter
Martin, Nicholas G
Whitfield, John B
Abbas, Shahid
Saleheen, Danish
Walters, Robin G
Holmes, Michael V
Black, Corri
Smith, Blair H
Baras, Aris
Justice, Anne E
Buring, Julie E
Ridker, Paul M
Chasman, Daniel I
Kooperberg, Charles
Tamiya, Gen
Yamamoto, Masayuki
van Heel, David A
Trembath, Richard C
Wei, Wei-Qi
Jarvik, Gail P
Namjou, Bahram
Hayes, M Geoffrey
Ritchie, Marylyn D
Jousilahti, Pekka
Salomaa, Veikko
Hveem, Kristian
Åsvold, Bjørn Olav
Kubo, Michiaki
Kamatani, Yoichiro
Okada, Yukinori
Murakami, Yoshinori
Kim, Bong-Jo
Thorsteinsdottir, Unnur
Stefansson, Kari
Zhang, Jifeng
Chen, YEugene
Ho, Yuk-Lam
Lynch, Julie A
Rader, Daniel J
Tsao, Philip S
Chang, Kyong-Mi
Cho, Kelly
O'Donnell, Christopher J
Gaziano, John M
Wilson, Peter W F
Frayling, Timothy M
Hirschhorn, Joel N
Kathiresan, Sekar
Mohlke, Karen L
Sun, Yan V
Morris, Andrew P
Boehnke, Michael
Brown, Christopher D
Natarajan, Pradeep
Deloukas, Panos
Willer, Cristen J
Assimes, Themistocles L
Peloso, Gina M
27.12.2022
268
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202301171487
https://urn.fi/URN:NBN:fi:tuni-202301171487
Kuvaus
Peer reviewed
Tiivistelmä
BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. RESULTS: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. CONCLUSIONS: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
Kokoelmat
- TUNICRIS-julkaisut [19195]
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Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Chen, Zhishan; Guo, Xingyi; Tao, Ran; Huyghe, Jeroen R.; Law, Philip J.; Fernandez-Rozadilla, Ceres; Ping, Jie; Jia, Guochong; Long, Jirong; Li, Chao; Shen, Quanhu; Xie, Yuhan; Timofeeva, Maria N.; Thomas, Minta; Schmit, Stephanie L.; Díez-Obrero, Virginia; Devall, Matthew; Moratalla-Navarro, Ferran; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Briggs, Sarah E.W.; Svinti, Victoria; Donnelly, Kevin; Farrington, Susan M.; Blackmur, James; Vaughan-Shaw, Peter G.; Shu, Xiao Ou; Lu, Yingchang; Broderick, Peter; Studd, James; Harrison, Tabitha A.; Conti, David V.; Schumacher, Fredrick R.; Melas, Marilena; Rennert, Gad; Obón-Santacana, Mireia; Martín-Sánchez, Vicente; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun Seog; Shin, Min Ho; Shin, Aesun; Ahn, Yoon Ok; Kim, Dong Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu Tang; Jia, Wei Hua; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko; Pai, Rish K.; Figueiredo, Jane C.; Haile, Robert W.; Gallinger, Steven; Woods, Michael O.; Newcomb, Polly A.; Duggan, David; Cheadle, Jeremy P.; Kaplan, Richard; Kerr, Rachel; Kerr, David; Kirac, Iva; Böhm, Jan; Mecklin, Jukka Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri A.; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan G.; Cajuso, Tatiana; Hänninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Männistö, Satu; Albanes, Demetrius; Weinstein, Stephanie J.; Ruiz-Narvaez, Edward; Palmer, Julie R.; Buchanan, Daniel D.; Platz, Elizabeth A.; Visvanathan, Kala; Ulrich, Cornelia M.; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter T.; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha L.; Potter, John D.; Tsilidis, Kostas K.; Schulze, Matthias B.; Gunter, Marc J.; Murphy, Neil; Castells, Antoni; Castellví-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Bishop, D. Timothy; Giles, Graham G.; Southey, Melissa C.; Idos, Gregory E.; McDonnell, Kevin J.; Abu-Ful, Zomoroda; Greenson, Joel K.; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu Ru; Steinfelder, Robert; Keku, Temitope O.; van Guelpen, Bethany; Hudson, Thomas J.; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja I.; Hayes, Richard B.; Martinez, Marie Elena; Thomas, Sushma S.; Pharoah, Paul D.P.; Larsson, Susanna C.; Yen, Yun; Lenz, Heinz Josef; White, Emily; Li, Li; Doheny, Kimberly F.; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew T.; Cruz-Correa, Marcia; Lindblom, Annika; Hunter, David J.; Joshi, Amit D.; Schafmayer, Clemens; Scacheri, Peter C.; Kundaje, Anshul; Schoen, Robert E.; Hampe, Jochen; Stadler, Zsofia K.; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Edlund, Christopher K.; Gauderman, W. James; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Chanock, Stephen J.; van Duijnhoven, Franzel; Feskens, Edith J.M.; Sakoda, Lori C.; Gago-Dominguez, Manuela; Wolk, Alicja; Pardini, Barbara; FitzGerald, Liesel M.; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie A.; Kooperberg, Charles; Li, Christopher I.; Lin, Yi; Prentice, Ross; Qu, Conghui; Bézieau, Stéphane; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Le Marchand, Loic; Wu, Anna H.; Qu, Chenxu; McNeil, Caroline E.; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian J.; Harris, Sarah E.; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Lau, Ken S.; Zhao, Hongyu; Hsu, Li; Cai, Qiuyin; Dunlop, Malcolm G.; Gruber, Stephen B.; Houlston, Richard S.; Moreno, Victor; Casey, Graham; Peters, Ulrike; Tomlinson, Ian; Zheng, Wei (2024)
articleGenome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought ... -
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
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articleIntroduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of ... -
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
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articleThe QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated ...