Haematological malignancies in patients with psoriatic arthritis overall and treated with TNF inhibitors : a Nordic cohort study
Cordtz, Rene Lindholm; Askling, Johan; Delcoigne, Benedicte; Smedby, Karin E.; Baecklund, Eva; Ballegaard, Christine; Isomäki, Pia; Aaltonen, Kalle; Gudbjornsson, Bjorn; Love, Thorvardur Jon; Provan, Sella Aarrestad; Michelsen, Brigitte; Sexton, Joseph; Dreyer, Lene; Hellgren, Karin (2022-12)
Cordtz, Rene Lindholm
Askling, Johan
Delcoigne, Benedicte
Smedby, Karin E.
Baecklund, Eva
Ballegaard, Christine
Isomäki, Pia
Aaltonen, Kalle
Gudbjornsson, Bjorn
Love, Thorvardur Jon
Provan, Sella Aarrestad
Michelsen, Brigitte
Sexton, Joseph
Dreyer, Lene
Hellgren, Karin
12 / 2022
e002776
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202301111337
https://urn.fi/URN:NBN:fi:tuni-202301111337
Kuvaus
Peer reviewed
Tiivistelmä
OBJECTIVES: To evaluate the risk of haematological malignancies in patients with psoriatic arthritis (PsA) overall, and in relation to treatment with tumour necrosis factor inhibitors (TNFi). METHODS: We identified that patients with PsA starting a first TNFi from the clinical rheumatology registers (CRR) in the five Nordic countries (n=10 621) and biologics-naïve PsA patients from (1) the CRR (n=18 705) and (2) the national patient registers (NPR, n=27 286, Sweden and Denmark) from 2006 through 2019. For Sweden and Denmark, general population comparators were matched 5:1 to PsA patients on birth year, year at start of follow-up and sex. By linkage to the national cancer registers in all countries, we collected information on haematological malignancies overall, and categorised into lymphoid or myeloid types. We estimated incidence rate ratios (IRRs) with 95% CIs using modified Poisson regression for TNFi-treated versus biologics-naïve PsA patients and versus the general population adjusted for age, sex, calendar period and country. RESULTS: During 59 827 person-years, 40 haematological malignancies occurred among TNFi-treated patients with PsA resulting in a pooled IRR of 0.96 (0.68-1.35) versus biologics-naïve PsA from CRR and an IRR of 0.84 (0.64-1.10) versus biologics-naïve PsA from NPR. The IRR of haematological malignancies in PsA overall versus general population comparators was 1.35 (1.17-1.55). The estimates were largely similar for lymphoid and myeloid malignancies. CONCLUSIONS: Treatment with TNFi in patients with PsA was not associated with an increased incidence of haematological malignancies. Conversely, a moderately increased underlying risk was seen in patients with PsA compared with the general population.
Kokoelmat
- TUNICRIS-julkaisut [19288]