Occupational risk variation of nasopharyngeal cancer in the Nordic countries
Carpén, Timo; Gille, Evelina; Hammarstedt-Nordenvall, Lalle; Hansen, Johnni; Heikkinen, Sanna; Lynge, Elsebeth; Selander, Jenny; Mehlum, Ingrid Sivesind; Torfadottir, Jóhanna Eyrún; Mäkitie, Antti; Pukkala, Eero (2022)
Carpén, Timo
Gille, Evelina
Hammarstedt-Nordenvall, Lalle
Hansen, Johnni
Heikkinen, Sanna
Lynge, Elsebeth
Selander, Jenny
Mehlum, Ingrid Sivesind
Torfadottir, Jóhanna Eyrún
Mäkitie, Antti
Pukkala, Eero
2022
1130
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202212129057
https://urn.fi/URN:NBN:fi:tuni-202212129057
Kuvaus
Peer reviewed
Tiivistelmä
Background: The aim of this study was to estimate occupational risk variation in the incidence of nasopharyngeal cancer (NPC) in a large population-based cohort of the Nordic Occupational Cancer (NOCCA) study. Methods: This study is based on a cohort of almost 15 million persons from Denmark, Finland, Iceland, Norway and Sweden, with 2898 nasopharyngeal cancer cases diagnosed in 1961–2005. The data on occupations were gathered from population censuses and cancer data from the national cancer registries. Standardized incidence ratios (SIR) with 95% confidence intervals (CI) were estimated using the national NPC incidence rates as the reference. Results: There were 1980 male and 918 female NPC patients. The highest SIRs of NPC were observed among male waiters (SIR 3.69, 95% CI 1.91–6.45) and cooks and stewards (SIR 2.24, 95% CI 1.16–3.91). Among women, launderers had the highest SIR of NPC (2.04, 95% CI 1.02–3.65). Significantly decreased SIRs were found among male farmers (SIR 0.79, 95% CI 0.68–0.92) and male textile workers (SIR 0.49, 95% CI 0.22–0.93). Conclusions: This study suggests that NPC may be associated with several work-related exposure agents such as smoking, kitchen air pollution and solvents. In future, occupational exposure-risk relations should be studied to understand more about causality and to assess effective prevention strategies.
Kokoelmat
- TUNICRIS-julkaisut [18592]