FDG-PET/CT-guided rebiopsy may find clinically unsuspicious transformation of follicular lymphoma
Rajamäki, Aino; Kuitunen, Hanne; Sorigue, Marc; Kokkonen, Salla Maarit; Kuittinen, Outi; Sunela, Kaisa (2023)
Rajamäki, Aino
Kuitunen, Hanne
Sorigue, Marc
Kokkonen, Salla Maarit
Kuittinen, Outi
Sunela, Kaisa
2023
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202208206575
https://urn.fi/URN:NBN:fi:tuni-202208206575
Kuvaus
Peer reviewed
Tiivistelmä
Aim: The purpose of the study was to evaluate the clinical impact of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) followed by a new biopsy from the site with maximum standardized uptake value (SUVmax) in case of high maximal SUV values, in detecting clinically unsuspected histologic transformations (HT) of follicular lymphoma (FL). Methods: This retrospective study included all the patients who had undergone FDG-PET/CT during primary diagnosis or relapse of FL between 2010 and 2020 at Oulu University Hospital. Results: The diagnosis changed from an indolent disease to a transformed lymphoma in >10% (7/63) of the patients who underwent diagnostic FDG-PET/CT. The HT risk associated with high SUVmax (>10) was 24% (7 of 29 performed biopsies). Four out of these seven patients with verified HT had no previous clinical suspicion of transformation. Conclusion: Our results suggest that a rebiopsy based on a high SUVmax in diagnostic FDG-PET/CT is valuable in detecting clinically unsuspected HT of FL.
Kokoelmat
- TUNICRIS-julkaisut [19188]