Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother–infant dyads
Nuzhat, Sharika; Palit, Parag; Mahfuz, Mustafa; Islam, Md. Ridwan; Hasan, S. M. Tafsir; Islam, M. Munirul; Sarker, Shafiqul A.; Kyle, David J.; Flannery, Robin L.; Vinjamuri, Anita; Lebrilla, Carlito B.; Ahmed, Tahmeed (2022-06)
Nuzhat, Sharika
Palit, Parag
Mahfuz, Mustafa
Islam, Md. Ridwan
Hasan, S. M. Tafsir
Islam, M. Munirul
Sarker, Shafiqul A.
Kyle, David J.
Flannery, Robin L.
Vinjamuri, Anita
Lebrilla, Carlito B.
Ahmed, Tahmeed
06 / 2022
9456
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202207116039
https://urn.fi/URN:NBN:fi:tuni-202207116039
Kuvaus
Peer reviewed
Tiivistelmä
Human milk oligosaccharides (HMOs) support the development of a healthy gut microbiome and the growth of infants. We aimed to determine the association of different HMOs with severe acute malnutrition (SAM) among Bangladeshi young infants. This study was nested within a single-blind, randomized, pilot clinical trial (NCT0366657). A total of 45 breastmilk samples from mothers of < 6 months old infants who had SAM (n = 26) or were non-malnourished (n = 19) and were analyzed for constituent HMOs. Of the infants with SAM, 14 (53.85%) had secretor mothers, and 11 (57.89%) of the non-malnourished infants had secretor mothers. A one-unit increase in the relative abundance of sialylated HMOs was associated with higher odds of SAM in age and sex adjusted model (aOR = 2.00, 90% CI 1.30, 3.06), in age, sex, and secretor status adjusted model (aOR = 1.96, 90% CI 1.29, 2.98), and also in age and sex adjusted model among non-secretor mothers (aOR = 2.86, 90% CI 1.07, 7.62). In adjusted models, there was no evidence of a statistically significant association between SAM and fucosylated or undecorated HMOs. Our study demonstrates that a higher relative abundance of sialylated HMOs in mothers’ breastmilk may have a negative impact on young infants’ nutritional status.
Kokoelmat
- TUNICRIS-julkaisut [18856]