Surface Stability of Azobenzene-Based Thin Films in Aqueous Environment : Light-Controllable Underwater Blistering
Audia, Biagio; Fedele, Chiara; Tone, Caterina M.; Cipparrone, Gabriella; Priimagi, Arri (2022)
Audia, Biagio
Fedele, Chiara
Tone, Caterina M.
Cipparrone, Gabriella
Priimagi, Arri
2022
2102125
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202206155679
https://urn.fi/URN:NBN:fi:tuni-202206155679
Kuvaus
Peer reviewed
Tiivistelmä
Azobenzene-based light-responsive thin films are emerging as appealing candidates for smart cell-culture substrates. Their attraction lies in the fact that they can be reversibly photo-patterned, providing a route for dynamically mimicking the remodeling of the extracellular matrix. However, since the cells need to be cultured in aqueous environment, a key parameter in the layout of any biological application is the stability of the surface underwater. In this work, the authors perform a detailed investigation on the surface stability of azobenzene-based thin films in water and in a biologically relevant aqueous medium in which surface blistering occurs, as a result of water–material interaction. The phenomenon arises due to film delamination, and it can be prevented by changing the underlying substrate, by an additional coating layer, or by photo-induced control over the film permeability. It is also shown that the blister orientation can be controlled with polarized light. Furthermore, a simple model based on osmotic pressure is proposed to explain the blister formation. These findings provide a comprehensive overview of the interaction between water and the photo-responsive film surface, pertinent for engineering biomaterials with enhanced dynamic control over the cell–material interface.
Kokoelmat
- TUNICRIS-julkaisut [16951]