Acute Side-effects of Different Radiotherapy Treatment Schedules in Early Prostate Cancer
Reinikainen, Petri; Kapanen, Mika; Luukkaala, Tiina; Kellokumpu-Lehtinen, Pirkko Liisa (2022)
Reinikainen, Petri
Kapanen, Mika
Luukkaala, Tiina
Kellokumpu-Lehtinen, Pirkko Liisa
2022
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202205164939
https://urn.fi/URN:NBN:fi:tuni-202205164939
Kuvaus
Peer reviewed
Tiivistelmä
BACKGROUND: Optimal radiation therapy (RT) fractionation in early prostate cancer in elderly patients is controversial. We compared acute toxicities of fractionation schedules: 78/2 Gy, 60/3 Gy and 36.25/7.25 Gy, in this single-centre study. We also evaluated the effect of the rectal immobilization system Rectafix on quality of life (QoL). PATIENTS AND METHODS: Seventy-three patients with one or two intermediate prostate cancer risk factors according to National Comprehensive Cancer Network criteria were recruited. Twenty-one patients were treated with 78/2 Gy and 60/3 Gy, and 31 patients with 36.25/7.25 Gy. Their QoL data were assessed with regard to genitourinary, gastrointestinal and sexual wellbeing at the beginning and end of RT and at 3 months after treatment. Rectafix was used in the 78/2 Gy and 60/3 Gy groups. RESULTS: There were no statistically significant QoL differences in between the treatment groups 3 months after RT. The 78/2 Gy group had significantly increased bowel movements between baseline and 3 months after RT (p=0.036). At 3 months after RT, this group also had significantly more erectile dysfunction than the 60/3 Gy group (p=0.025). At the end of RT, the 78/2 Gy group had more symptoms than the 36.25/7.25 Gy group. Rectafix did not reduce acute toxicities in the 78/2 Gy or 60/3 Gy groups. CONCLUSION: Treatment with the 78/2 Gy schedule is no longer to be recommended due to its increased acute toxicity compared to treatments of 60/3 Gy and 36.25/7.25 Gy. The shortest schedule of 36.25 Gy in five fractions seems to be a convenient treatment option with tolerable acute toxicity.
Kokoelmat
- TUNICRIS-julkaisut [19190]