O,O-Silyl Group Migrations in Quinic Acid Derivatives : An Opportunity for Divergent Synthesis
Holmstedt, Suvi; Efimov, Alexander; Candeias, Nuno R. (2021)
Holmstedt, Suvi
Efimov, Alexander
Candeias, Nuno R.
2021
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202110157608
https://urn.fi/URN:NBN:fi:tuni-202110157608
Kuvaus
Peer reviewed
Tiivistelmä
The O,O-silyl group migrations on a quinic acid-derived cyclitol have been studied, and the ease of migration was observed to be dependent on the silicon substituents and reaction conditions. Conditions were found to improve the formation of a main isomer during the O,O-silyl group migrations that could be integrated into the formal synthesis of vitamin D receptor modulator VS-105 and in the first total synthesis of a metabolite from the African ant Crematogaster nigriceps.
Kokoelmat
- TUNICRIS-julkaisut [15325]