Meta-analyses identify DNA methylation associated with kidney function and damage
Estonian Biobank Research Team; Genetics of DNA Methylation Consortium; Schlosser, Pascal; Tin, Adrienne; Matias-Garcia, Pamela R.; Thio, Chris H.L.; Joehanes, Roby; Liu, Hongbo; Weihs, Antoine; Yu, Zhi; Hoppmann, Anselm; Grundner-Culemann, Franziska; Min, Josine L.; Adeyemo, Adebowale A.; Agyemang, Charles; Ärnlöv, Johan; Aziz, Nasir A.; Baccarelli, Andrea; Bochud, Murielle; Brenner, Hermann; Breteler, Monique M.B.; Carmeli, Cristian; Chaker, Layal; Chambers, John C.; Cole, Shelley A.; Coresh, Josef; Corre, Tanguy; Correa, Adolfo; Cox, Simon R.; de Klein, Niek; Delgado, Graciela E.; Domingo-Relloso, Arce; Eckardt, Kai Uwe; Ekici, Arif B.; Endlich, Karlhans; Evans, Kathryn L.; Floyd, James S.; Fornage, Myriam; Franke, Lude; Fraszczyk, Eliza; Gao, Xu; Gào, Xīn; Ghanbari, Mohsen; Ghasemi, Sahar; Gieger, Christian; Greenland, Philip; Grove, Megan L.; Harris, Sarah E.; Hemani, Gibran; Hurme, Mikko A.; Lehtimäki, Terho; Mishra, Pashupati P. (2021-12)
Estonian Biobank Research Team
Genetics of DNA Methylation Consortium
Schlosser, Pascal
Tin, Adrienne
Matias-Garcia, Pamela R.
Thio, Chris H.L.
Joehanes, Roby
Liu, Hongbo
Weihs, Antoine
Yu, Zhi
Hoppmann, Anselm
Grundner-Culemann, Franziska
Min, Josine L.
Adeyemo, Adebowale A.
Agyemang, Charles
Ärnlöv, Johan
Aziz, Nasir A.
Baccarelli, Andrea
Bochud, Murielle
Brenner, Hermann
Breteler, Monique M.B.
Carmeli, Cristian
Chaker, Layal
Chambers, John C.
Cole, Shelley A.
Coresh, Josef
Corre, Tanguy
Correa, Adolfo
Cox, Simon R.
de Klein, Niek
Delgado, Graciela E.
Domingo-Relloso, Arce
Eckardt, Kai Uwe
Ekici, Arif B.
Endlich, Karlhans
Evans, Kathryn L.
Floyd, James S.
Fornage, Myriam
Franke, Lude
Fraszczyk, Eliza
Gao, Xu
Gào, Xīn
Ghanbari, Mohsen
Ghasemi, Sahar
Gieger, Christian
Greenland, Philip
Grove, Megan L.
Harris, Sarah E.
Hemani, Gibran
Hurme, Mikko A.
Lehtimäki, Terho
Mishra, Pashupati P.
12 / 2021
7174
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202112289546
https://urn.fi/URN:NBN:fi:tuni-202112289546
Kuvaus
Peer reviewed
Tiivistelmä
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.
Kokoelmat
- TUNICRIS-julkaisut [19034]