Influence of red blood cell indices on HbA1c performance in detecting dysglycaemia in a Singapore preconception cohort study
Loy, See Ling; Lin, Jinjie; Cheung, Yin Bun; Sreedharan, Aravind Venkatesh; Chin, Xinyi; Godfrey, Keith M.; Tan, Kok Hian; Shek, Lynette Pei Chi; Chong, Yap Seng; Leow, Melvin Khee Shing; Khoo, Chin Meng; Lee, Yung Seng; Chan, Shiao Yng; Lek, Ngee; Chan, Jerry Kok Yen; Yap, Fabian (2021-10)
Loy, See Ling
Lin, Jinjie
Cheung, Yin Bun
Sreedharan, Aravind Venkatesh
Chin, Xinyi
Godfrey, Keith M.
Tan, Kok Hian
Shek, Lynette Pei Chi
Chong, Yap Seng
Leow, Melvin Khee Shing
Khoo, Chin Meng
Lee, Yung Seng
Chan, Shiao Yng
Lek, Ngee
Chan, Jerry Kok Yen
Yap, Fabian
10 / 2021
20850
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202111178460
https://urn.fi/URN:NBN:fi:tuni-202111178460
Kuvaus
Peer reviewed
Tiivistelmä
Abnormalities of red blood cell (RBC) indices may affect glycated haemoglobin (HbA1c) levels. We assessed the influence of haemoglobin (Hb) and mean corpuscular volume (MCV) on the performance of HbA1c in detecting dysglycaemia among reproductive aged women planning to conceive. Women aged 18–45 years (n = 985) were classified as normal (12 ≤ Hb ≤ 16 g/dL and 80 ≤ MCV ≤ 100 fL) and abnormal (Hb < 12 g/dL and/or MCV < 80 fL). The Area Under the Receiver Operating Characteristic (AUROC) curve was used to determine the performance of HbA1c in detecting dysglycaemic status (prediabetes and diabetes). There were 771 (78.3%) women with normal RBC indices. The AUROCs for the normal and abnormal groups were 0.75 (95% confidence interval 0.69, 0.81) and 0.80 (0.70, 0.90), respectively, and were not statistically different from one another [difference 0.04 (− 0.16, 0.08)]. Further stratification by ethnicity showed no difference between the two groups among Chinese and Indian women. However, Malay women with normal RBC indices displayed lower AUROC compared to those with abnormal RBC indices (0.71 (0.55, 0.87) vs. 0.98 (0.93, 1.00), p = 0.002). The results suggest that the performance of HbA1c in detecting dysglycaemia was not influenced by abnormal RBC indices based on low Hb and/or low MCV. However, there may be ethnic variations among them.
Kokoelmat
- TUNICRIS-julkaisut [16977]