Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective and bipolar disorder
Mazumder, Atiqul Haq; Barnett, Jennifer; Isometsä, Erkki Tapio; Lindberg, Nina; Torniainen-Holm, Minna; Lähteenvuo, Markku; Lahdensuo, Kaisla; Kerkelä, Martta; Ahola-Olli, Ari; Hietala, Jarmo; Kampman, Olli; Kieseppä, Tuula; Jukuri, Tuomas; Häkkinen, Katja; Cederlöf, Erik; Haaki, Willehard; Kajanne, Risto; Wegelius, Asko; Männynsalo, Teemu; Niemi-Pynttäri, Jussi; Suokas, Kimmo; Lönnqvist, Jouko; Tiihonen, Jari; Paunio, Tiina; Vainio, Seppo Juhani; Palotie, Aarno; Niemelä, Solja; Suvisaari, Jaana; Veijola, Juha (2021)
Mazumder, Atiqul Haq
Barnett, Jennifer
Isometsä, Erkki Tapio
Lindberg, Nina
Torniainen-Holm, Minna
Lähteenvuo, Markku
Lahdensuo, Kaisla
Kerkelä, Martta
Ahola-Olli, Ari
Hietala, Jarmo
Kampman, Olli
Kieseppä, Tuula
Jukuri, Tuomas
Häkkinen, Katja
Cederlöf, Erik
Haaki, Willehard
Kajanne, Risto
Wegelius, Asko
Männynsalo, Teemu
Niemi-Pynttäri, Jussi
Suokas, Kimmo
Lönnqvist, Jouko
Tiihonen, Jari
Paunio, Tiina
Vainio, Seppo Juhani
Palotie, Aarno
Niemelä, Solja
Suvisaari, Jaana
Veijola, Juha
2021
1422
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202111168439
https://urn.fi/URN:NBN:fi:tuni-202111168439
Kuvaus
Peer reviewed
Tiivistelmä
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.
Kokoelmat
- TUNICRIS-julkaisut [16929]