Association of maternal prenatal selenium concentration and preterm birth : A multicountry meta-analysis
Monangi, Nagendra; Xu, Huan; Khanam, Rasheda; Khan, Waqasuddin; Deb, Saikat; Pervin, Jesmin; Price, Joan T.; INTERBIO-21st Study Consortium; Kennedy, Stephen H.; Al Mahmud, Abdullah; Fan, Yuemei; Le, Thanh Q.; Care, Angharad; Landero, Julio A.; Combs, Gerald F.; Belling, Elizabeth; Chappell, Joanne; Kong, Fansheng; Lacher, Criag; Ahmed, Salahuddin; Chowdhury, Nabidul Haque; Rahman, Sayedur; Kabir, Furqan; Nisar, Imran; Hotwani, Aneeta; Mehmood, Usma; Nizar, Ambreen; Khalid, Javairia; Dhingra, Usha; Dutta, Arup; Ali, Said; Aftab, Fahad; Juma, Mohammed Hamad; Rahman, Monjur; Vwalika, Bellington; Musonda, Patrick; Ahmed, Tahmeed; Islam, Md Munirul; Ashorn, Ulla; Maleta, Kenneth; Hallman, Mikko; Goodfellow, Laura; Gupta, Juhi K.; Alfirevic, Ana; Murphy, Susan; Rand, Larry; Ryckman, Kelli K.; Murray, Jeffrey C.; Bahl, Rajiv; Litch, James A.; Ashorn, Per (2021-09-13)
Monangi, Nagendra
Xu, Huan
Khanam, Rasheda
Khan, Waqasuddin
Deb, Saikat
Pervin, Jesmin
Price, Joan T.
INTERBIO-21st Study Consortium
Kennedy, Stephen H.
Al Mahmud, Abdullah
Fan, Yuemei
Le, Thanh Q.
Care, Angharad
Landero, Julio A.
Combs, Gerald F.
Belling, Elizabeth
Chappell, Joanne
Kong, Fansheng
Lacher, Criag
Ahmed, Salahuddin
Chowdhury, Nabidul Haque
Rahman, Sayedur
Kabir, Furqan
Nisar, Imran
Hotwani, Aneeta
Mehmood, Usma
Nizar, Ambreen
Khalid, Javairia
Dhingra, Usha
Dutta, Arup
Ali, Said
Aftab, Fahad
Juma, Mohammed Hamad
Rahman, Monjur
Vwalika, Bellington
Musonda, Patrick
Ahmed, Tahmeed
Islam, Md Munirul
Ashorn, Ulla
Maleta, Kenneth
Hallman, Mikko
Goodfellow, Laura
Gupta, Juhi K.
Alfirevic, Ana
Murphy, Susan
Rand, Larry
Ryckman, Kelli K.
Murray, Jeffrey C.
Bahl, Rajiv
Litch, James A.
Ashorn, Per
13.09.2021
e005856
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202110067416
https://urn.fi/URN:NBN:fi:tuni-202110067416
Kuvaus
Peer reviewed
Tiivistelmä
Background Selenium (Se), an essential trace mineral, has been implicated in preterm birth (PTB). We aimed to determine the association of maternal Se concentrations during pregnancy with PTB risk and gestational duration in a large number of samples collected from diverse populations. Methods Gestational duration data and maternal plasma or serum samples of 9946 singleton live births were obtained from 17 geographically diverse study cohorts. Maternal Se concentrations were determined by inductively coupled plasma mass spectrometry analysis. The associations between maternal Se with PTB and gestational duration were analysed using logistic and linear regressions. The results were then combined using fixed-effect and random-effect meta-analysis. Findings In all study samples, the Se concentrations followed a normal distribution with a mean of 93.8 ng/mL (SD: 28.5 ng/mL) but varied substantially across different sites. The fixed-effect meta-analysis across the 17 cohorts showed that Se was significantly associated with PTB and gestational duration with effect size estimates of an OR=0.95 (95% CI: 0.9 to 1.00) for PTB and 0.66 days (95% CI: 0.38 to 0.94) longer gestation per 15 ng/mL increase in Se concentration. However, there was a substantial heterogeneity among study cohorts and the random-effect meta-analysis did not achieve statistical significance. The largest effect sizes were observed in UK (Liverpool) cohort, and most significant associations were observed in samples from Malawi. Interpretation While our study observed statistically significant associations between maternal Se concentration and PTB at some sites, this did not generalise across the entire cohort. Whether population-specific factors explain the heterogeneity of our findings warrants further investigation. Further evidence is needed to understand the biologic pathways, clinical efficacy and safety, before changes to antenatal nutritional recommendations for Se supplementation are considered.
Kokoelmat
- TUNICRIS-julkaisut [16929]