Predictors of poststroke aphasia recovery : A systematic review - informed individual participant data meta-analysis
The Rehabilitation and Recovery of People with Aphasia after Stroke (RELEASE) Collaborators; Ali, Myzoon; VandenBerg, Kathryn; Williams, Linda J.; Williams, Louise R.; Abo, Masahiro; Becker, Frank; Bowen, Audrey; Brandenburg, Caitlin; Breitenstein, Caterina; Bruehl, Stefanie; Copland, David A.; Cranfill, Tamara B.; di Pietro-Bachmann, Marie; Enderby, Pamela; Fillingham, Joanne; Galli, Federica Lucia; Gandolfi, Marialuisa; Glize, Bertrand; Godecke, Erin; Hawkins, Neil; Hilari, Katerina; Hinckley, Jacqueline; Horton, Simon; Howard, David; Jaecks, Petra; Jefferies, Elizabeth; Jesus, Luis M.T.; Kambanaros, Maria; Kang, Eun Kyoung; Khedr, Eman M.; Kong, Anthony Pak Hin; Kukkonen, Tarja; Laganaro, Marina; Ralph, Matthew A.Lambon; Laska, Ann Charlotte; Leemann, Béatrice; Leff, Alexander P.; Lima, Roxele R.; Lorenz, Antje; Whinney, Brian Mac; Marshall, Rebecca Shisler; Mattioli, Flavia; Maviş, Ilknur; Meinzer, Marcus; Nilipour, Reza; Noé, Enrique; Paik, Nam Jong; Palmer, Rebecca; Papathanasiou, Ilias (2021)
The Rehabilitation and Recovery of People with Aphasia after Stroke (RELEASE) Collaborators
Ali, Myzoon
VandenBerg, Kathryn
Williams, Linda J.
Williams, Louise R.
Abo, Masahiro
Becker, Frank
Bowen, Audrey
Brandenburg, Caitlin
Breitenstein, Caterina
Bruehl, Stefanie
Copland, David A.
Cranfill, Tamara B.
di Pietro-Bachmann, Marie
Enderby, Pamela
Fillingham, Joanne
Galli, Federica Lucia
Gandolfi, Marialuisa
Glize, Bertrand
Godecke, Erin
Hawkins, Neil
Hilari, Katerina
Hinckley, Jacqueline
Horton, Simon
Howard, David
Jaecks, Petra
Jefferies, Elizabeth
Jesus, Luis M.T.
Kambanaros, Maria
Kang, Eun Kyoung
Khedr, Eman M.
Kong, Anthony Pak Hin
Kukkonen, Tarja
Laganaro, Marina
Ralph, Matthew A.Lambon
Laska, Ann Charlotte
Leemann, Béatrice
Leff, Alexander P.
Lima, Roxele R.
Lorenz, Antje
Whinney, Brian Mac
Marshall, Rebecca Shisler
Mattioli, Flavia
Maviş, Ilknur
Meinzer, Marcus
Nilipour, Reza
Noé, Enrique
Paik, Nam Jong
Palmer, Rebecca
Papathanasiou, Ilias
2021
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202109066965
https://urn.fi/URN:NBN:fi:tuni-202109066965
Kuvaus
Peer reviewed
Tiivistelmä
BACKGROUND AND PURPOSE: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. METHODS: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. RESULTS: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4–165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3–26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0–20.9], +6.1 correct on AAT Token Test [CI, 3.2–8.9]; +9.3 Boston Naming Test points [CI, 4.7–13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5–1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9–24.4]; +5.3 correct on AAT Token Test [CI, 1.7–8.8]; +11.1 Boston Naming Test points [CI, 5.7–16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7–1.4]) conferred the greatest absolute change-from-baseline across each language domain. Improvements in language scores from baseline diminished with increasing age and aphasia chronicity. Data exhibited no significant statistical heterogeneity. Risk-of-bias was low to moderate-low. CONCLUSIONS: Earlier intervention for poststroke aphasia was crucial to maximize language recovery across a range of language domains, although recovery continued to be observed to a lesser extent beyond 6 months poststroke.
Kokoelmat
- TUNICRIS-julkaisut [16983]