Opium use reporting error in case-control studies : Neighborhood controls versus hospital visitor controls
Mohebbi, Elham; Rashidian, Hamideh; Tahami, Ahmad Naghibzadeh; Haghdoost, Ali Akbar; Rahimi-Movaghar, Afarin; Seyyedsalehi, Monireh Sadat; Rezaianzadeh, Abass; Marzban, Maryam; Moradi, Abdolvahab; Gholipour, Mahin; Hadji, Maryam; Kamangar, Farin; Zendehdel, Kazem (2021)
Mohebbi, Elham
Rashidian, Hamideh
Tahami, Ahmad Naghibzadeh
Haghdoost, Ali Akbar
Rahimi-Movaghar, Afarin
Seyyedsalehi, Monireh Sadat
Rezaianzadeh, Abass
Marzban, Maryam
Moradi, Abdolvahab
Gholipour, Mahin
Hadji, Maryam
Kamangar, Farin
Zendehdel, Kazem
2021
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202107276373
https://urn.fi/URN:NBN:fi:tuni-202107276373
Kuvaus
Peer reviewed
Tiivistelmä
Background: There are relatively scant data to determine whether hospital visitors could serve as a proper source of controls in case-control studies of illicit drug use. The aim of this study was to evaluate using neighborhood versus hospital visitor controls in reporting opium use. Methods: We used data from 2 independent case-control studies of cancer in Iran. In the first study, controls were selected from neighborhoods of the patients. For the second one, controls were selected from among hospital visitors. In the latter study, hospital visitors were companions of the patients or others visiting the hospital for reasons other than disease treatment. We used stata (version 12; Stata Corp (for all analyses and with a significance level of 0.05. Results: Data from 616 of neighborhood controls and 414 of hospital visitor controls were analyzed. Opium point prevalence among men was significantly higher in hospital visitors than neighborhood controls (43.3% vs 32.2%; P = 0.047), while the prevalence of cigarette smoking was very similar in both control groups (46.3% vs 47.2%; P = .847). Using a logi stic regression analysis, in an unadjusted analysis, neighborhood controls were less likely to report opium use in both genders, with (unadjusted OR = 0.77; 95% CI: 0.59,1). After adjusting for potential confounders, the differences of opium use between the 2 control groups became more pronounced (Adjusted OR = 0.26; 95% CI: 0.10, 0.69). Conclusion: Because of the similarity of reporting cigarette smoking among neighborhood controls but substantially lower reporting of opium use among them, we concluded that neighborhood controls underreport opium use—a sensitive question— and that using neighborhood control biases the findings in case-control studies. Hospital visitor controls may be more appropriate than neighborhood controls for case-control studies of illicit drugs.
Kokoelmat
- TUNICRIS-julkaisut [19293]