Microcutting of living tissue slices and stem cell colonies by using mechanical tool

Abstract

There is a growing need for methods to cut living tissues in vitro and cell cultures in microscale in biological and medical research. This paper presents two different microrobotic methods for cutting: mechanical microdissection using a sharp needle and liquid jet cutting utilizing a pressured liquid jet. Test devices for both the methods were built and the experiments were conducted with thin tissue slices and stem cell colonies. The devices built as well as the structure of the experiments and the results gained are discussed in this paper and the methods are compared with each other.