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Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

FINNPEC Consortium; GOPEC Consortium; Steinthorsdottir, Valgerdur; McGinnis, Ralph; Williams, Nicholas O; Stefansdottir, Lilja; Thorleifsson, Gudmar; Shooter, Scott; Fadista, João; Sigurdsson, Jon K; Auro, Kirsi M; Berezina, Galina; Borges, Maria-Carolina; Bumpstead, Suzannah; Bybjerg-Grauholm, Jonas; Colgiu, Irina; Dolby, Vivien A; Dudbridge, Frank; Engel, Stephanie M; Franklin, Christopher S; Frigge, Michael L; Frisbaek, Yr; Geirsson, Reynir T; Geller, Frank; Gretarsdottir, Solveig; Gudbjartsson, Daniel F; Harmon, Quaker; Hougaard, David Michael; Hegay, Tatyana; Helgadottir, Anna; Hjartardottir, Sigrun; Jääskeläinen, Tiina; Johannsdottir, Hrefna; Jonsdottir, Ingileif; Juliusdottir, Thorhildur; Kalsheker, Noor; Kasimov, Abdumadjit; Kemp, John P; Kivinen, Katja; Klungsøyr, Kari; Lee, Wai K; Melbye, Mads; Miedzybrodska, Zosia; Moffett, Ashley; Najmutdinova, Dilbar; Nishanova, Firuza; Olafsdottir, Thorunn; Perola, Markus; Pipkin, Fiona Broughton; Poston, Lucilla; Prescott, Gordon; Laivuori, Hannele (2020-11-25)

 
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s41467_020_19733_6.pdf (1.619Mt)
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FINNPEC Consortium
GOPEC Consortium
Steinthorsdottir, Valgerdur
McGinnis, Ralph
Williams, Nicholas O
Stefansdottir, Lilja
Thorleifsson, Gudmar
Shooter, Scott
Fadista, João
Sigurdsson, Jon K
Auro, Kirsi M
Berezina, Galina
Borges, Maria-Carolina
Bumpstead, Suzannah
Bybjerg-Grauholm, Jonas
Colgiu, Irina
Dolby, Vivien A
Dudbridge, Frank
Engel, Stephanie M
Franklin, Christopher S
Frigge, Michael L
Frisbaek, Yr
Geirsson, Reynir T
Geller, Frank
Gretarsdottir, Solveig
Gudbjartsson, Daniel F
Harmon, Quaker
Hougaard, David Michael
Hegay, Tatyana
Helgadottir, Anna
Hjartardottir, Sigrun
Jääskeläinen, Tiina
Johannsdottir, Hrefna
Jonsdottir, Ingileif
Juliusdottir, Thorhildur
Kalsheker, Noor
Kasimov, Abdumadjit
Kemp, John P
Kivinen, Katja
Klungsøyr, Kari
Lee, Wai K
Melbye, Mads
Miedzybrodska, Zosia
Moffett, Ashley
Najmutdinova, Dilbar
Nishanova, Firuza
Olafsdottir, Thorunn
Perola, Markus
Pipkin, Fiona Broughton
Poston, Lucilla
Prescott, Gordon
Laivuori, Hannele
25.11.2020


5976
doi:10.1038/s41467-020-19733-6
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202101171392

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Peer reviewed
Tiivistelmä
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
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Kalevantie 5
PL 617
33014 Tampereen yliopisto
oa[@]tuni.fi | Tietosuoja | Saavutettavuusseloste